Gene description for GRIN2C
Gene name glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Gene symbol GRIN2C
Other names/aliases GluN2C
NMDAR2C
NR2C
Species Homo sapiens
 Database cross references - GRIN2C
ExoCarta ExoCarta_2905
Vesiclepedia VP_2905
Entrez Gene 2905
HGNC 4587
MIM 138254
UniProt Q14957  
 GRIN2C identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GRIN2C
Molecular Function
    NMDA glutamate receptor activity GO:0004972 IBA
    NMDA glutamate receptor activity GO:0004972 IDA
    NMDA glutamate receptor activity GO:0004972 TAS
    monoatomic cation channel activity GO:0005261 IEA
    protein binding GO:0005515 IPI
    transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315 IBA
Biological Process
    glutamate receptor signaling pathway GO:0007215 TAS
    brain development GO:0007420 NAS
    response to wounding GO:0009611 IEA
    directional locomotion GO:0033058 IEA
    ionotropic glutamate receptor signaling pathway GO:0035235 ISO
    synaptic transmission, glutamatergic GO:0035249 IBA
    negative regulation of protein catabolic process GO:0042177 IEA
    regulation of synaptic plasticity GO:0048167 ISS
    regulation of synaptic plasticity GO:0048167 NAS
    regulation of neuronal synaptic plasticity GO:0048168 NAS
    neuromuscular process controlling balance GO:0050885 IEA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO
    excitatory postsynaptic potential GO:0060079 IBA
    long-term synaptic potentiation GO:0060291 IBA
    calcium ion transmembrane import into cytosol GO:0097553 IDA
    monoatomic cation transmembrane transport GO:0098655 IDA
    monoatomic cation transmembrane transport GO:0098655 ISS
    excitatory chemical synaptic transmission GO:0098976 NAS
    protein localization to postsynaptic membrane GO:1903539 IEA
    regulation of monoatomic cation transmembrane transport GO:1904062 ISO
    positive regulation of excitatory postsynaptic potential GO:2000463 ISO
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    NMDA selective glutamate receptor complex GO:0017146 IBA
    NMDA selective glutamate receptor complex GO:0017146 IDA
    NMDA selective glutamate receptor complex GO:0017146 ISS
    NMDA selective glutamate receptor complex GO:0017146 TAS
    postsynaptic membrane GO:0045211 ISS
    postsynaptic membrane GO:0045211 NAS
    postsynaptic density membrane GO:0098839 IBA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified GRIN2C in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GRIN2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DDX19B 11269
Affinity Capture-MS Homo sapiens
2 GRIN1 2902
Affinity Capture-Western Homo sapiens
3 ERBB2IP 55914
Reconstituted Complex Homo sapiens
4 PTPRK 5796
Affinity Capture-MS Homo sapiens
5 TUBA4A 7277
Affinity Capture-MS Homo sapiens
6 OAF 220323
Affinity Capture-MS Homo sapiens
7 HSPA5 3309
Affinity Capture-MS Homo sapiens
8 ATP12A 479
Affinity Capture-MS Homo sapiens
9 TSEN2  
Affinity Capture-MS Homo sapiens
10 MANBA 4126
Affinity Capture-MS Homo sapiens
11 DLG4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 DLG3 1741
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 BCHE 590
Affinity Capture-MS Homo sapiens
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