Gene description for GRIN2C
Gene name glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Gene symbol GRIN2C
Other names/aliases GluN2C
NMDAR2C
NR2C
Species Homo sapiens
 Database cross references - GRIN2C
ExoCarta ExoCarta_2905
Vesiclepedia VP_2905
Entrez Gene 2905
HGNC 4587
MIM 138254
UniProt Q14957  
 GRIN2C identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for GRIN2C
Molecular Function
    N-methyl-D-aspartate selective glutamate receptor activity GO:0004972 IEA
    PDZ domain binding GO:0030165 IEA
    extracellular-glutamate-gated ion channel activity GO:0005234 IBA
    cation channel activity GO:0005261 IEA
    protein N-terminus binding GO:0047485 IEA
    protein binding GO:0005515 IPI
Biological Process
    ionotropic glutamate receptor signaling pathway GO:0035235 IBA
    neuromuscular process controlling balance GO:0050885 IEA
    transport GO:0006810 TAS
    directional locomotion GO:0033058 IEA
    regulation of excitatory postsynaptic membrane potential GO:0060079 IEA
    negative regulation of protein catabolic process GO:0042177 IEA
    ion transmembrane transport GO:0034220 IBA
    synaptic transmission GO:0007268 TAS
    protein localization GO:0008104 IEA
    synaptic transmission, glutamatergic GO:0035249 IBA
    cation transmembrane transport GO:0098655 IEA
    glutamate receptor signaling pathway GO:0007215 TAS
    response to wounding GO:0009611 IEA
Subcellular Localization
    postsynaptic membrane GO:0045211 IBA
    postsynaptic density GO:0014069 IEA
    integral component of plasma membrane GO:0005887 TAS
    dendrite GO:0030425 IBA
    cell junction GO:0030054 IEA
    N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified GRIN2C in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GRIN2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLG4  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 ERBB2IP 55914
Reconstituted Complex Homo sapiens
3 DLG3 1741
Invitro Homo sapiens
Invivo Homo sapiens
4 IL16  
Two-hybrid Homo sapiens
View the network image/svg+xml



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