Gene description for BCHE
Gene name butyrylcholinesterase
Gene symbol BCHE
Other names/aliases CHE1
CHE2
E1
Species Homo sapiens
 Database cross references - BCHE
ExoCarta ExoCarta_590
Entrez Gene 590
HGNC 983
MIM 177400
UniProt P06276  
 BCHE identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 22723089    
 Gene ontology annotations for BCHE
Molecular Function
    choline binding GO:0033265 IEA
    catalytic activity GO:0003824 NAS
    enzyme binding GO:0019899 NAS
    cholinesterase activity GO:0004104 IDA
    beta-amyloid binding GO:0001540 NAS
    identical protein binding GO:0042802 IPI
    acetylcholinesterase activity GO:0003990 ISS
Biological Process
    response to glucocorticoid GO:0051384 IEA
    negative regulation of synaptic transmission GO:0050805 IEA
    choline metabolic process GO:0019695 IEA
    cellular protein metabolic process GO:0044267 TAS
    response to alkaloid GO:0043279 IEA
    response to drug GO:0042493 IEA
    learning GO:0007612 IEA
    cocaine metabolic process GO:0050783 TAS
    response to folic acid GO:0051593 IEA
    neuroblast differentiation GO:0014016 IEA
    negative regulation of cell proliferation GO:0008285 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    endoplasmic reticulum lumen GO:0005788 IEA
    blood microparticle GO:0072562 IDA
    nuclear envelope lumen GO:0005641 IEA
    extracellular space GO:0005615 IBA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified BCHE in exosomes
1
Experiment ID 143
ISEV standards
EM
EV Biophysical techniques
HSP70|HSP90|RAB5
EV Cytosolic markers
LAMP2|CD9
EV Membrane markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for BCHE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COLQ  
Invitro Homo sapiens
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