Gene description for TREM1
Gene name triggering receptor expressed on myeloid cells 1
Gene symbol TREM1
Other names/aliases CD354
TREM-1
Species Homo sapiens
 Database cross references - TREM1
ExoCarta ExoCarta_54210
Vesiclepedia VP_54210
Entrez Gene 54210
HGNC 17760
MIM 605085
UniProt Q9NP99  
 TREM1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TREM1
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IBA
    transmembrane signaling receptor activity GO:0004888 IDA
    signaling receptor activity GO:0038023 TAS
    scaffold protein binding GO:0097110 IPI
    receptor decoy activity GO:0140319 IDA
Biological Process
    adaptive immune response GO:0002250 IEA
    cytokine production involved in immune response GO:0002367 IBA
    humoral immune response GO:0006959 TAS
    neutrophil chemotaxis GO:0030593 IBA
    intracellular signal transduction GO:0035556 TAS
    innate immune response GO:0045087 IEA
    neutrophil-mediated killing of gram-negative bacterium GO:0070945 IBA
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
 Experiment description of studies that identified TREM1 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TREM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NR2F2  
Affinity Capture-MS Homo sapiens
2 SEC11A 23478
Affinity Capture-MS Homo sapiens
3 SEL1L3  
Affinity Capture-MS Homo sapiens
4 MZT2B 80097
Affinity Capture-MS Homo sapiens
5 KIAA0368 23392
Affinity Capture-MS Homo sapiens
6 ATP12A 479
Affinity Capture-MS Homo sapiens
7 ASB9  
Affinity Capture-MS Homo sapiens
8 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
9 TREM1 54210
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
10 TYROBP  
Affinity Capture-Western Homo sapiens
11 SPCS1 28972
Affinity Capture-MS Homo sapiens
12 FAM127A  
Affinity Capture-MS Homo sapiens
13 TTK 7272
Affinity Capture-MS Homo sapiens
14 SPCS2 9789
Affinity Capture-MS Homo sapiens
15 DDX58 23586
Affinity Capture-RNA Homo sapiens
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