Gene description for CHST11
Gene name carbohydrate (chondroitin 4) sulfotransferase 11
Gene symbol CHST11
Other names/aliases C4ST
C4ST-1
C4ST1
HSA269537
Species Homo sapiens
 Database cross references - CHST11
ExoCarta ExoCarta_50515
Vesiclepedia VP_50515
Entrez Gene 50515
HGNC 17422
MIM 610128
UniProt Q9NPF2  
 CHST11 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CHST11
Molecular Function
    dermatan 4-sulfotransferase GO:0001537 IDA
    sulfotransferase activity GO:0008146 IBA
    chondroitin 4-sulfotransferase activity GO:0047756 IDA
    chondroitin 4-sulfotransferase activity GO:0047756 TAS
    N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity GO:0050659 IEA
Biological Process
    in utero embryonic development GO:0001701 IEA
    chondrocyte development GO:0002063 IEA
    apoptotic process GO:0006915 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    respiratory gaseous exchange by respiratory system GO:0007585 IEA
    post-embryonic development GO:0009791 IEA
    carbohydrate biosynthetic process GO:0016051 IEA
    proteoglycan biosynthetic process GO:0030166 IBA
    chondroitin sulfate biosynthetic process GO:0030206 IDA
    chondroitin sulfate biosynthetic process GO:0030206 TAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    polysaccharide localization GO:0033037 IEA
    post-anal tail morphogenesis GO:0036342 IEA
    regulation of cell population proliferation GO:0042127 IEA
    embryonic digit morphogenesis GO:0042733 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    developmental growth GO:0048589 IEA
    embryonic viscerocranium morphogenesis GO:0048703 IEA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 NAS
 Experiment description of studies that identified CHST11 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CHST11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 YWHAE 7531
Reconstituted Complex Homo sapiens
3 SCN4A  
Affinity Capture-MS Homo sapiens
4 CHRNB2  
Affinity Capture-MS Homo sapiens
5 SDF4 51150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TMEM59 9528
Affinity Capture-MS Homo sapiens
7 SLC2A12 154091
Affinity Capture-MS Homo sapiens
8 NRSN1  
Affinity Capture-MS Homo sapiens
9 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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