Gene description for KIAA1109
Gene name KIAA1109
Gene symbol KIAA1109
Other names/aliases FSA
Tweek
Species Homo sapiens
 Database cross references - KIAA1109
ExoCarta ExoCarta_84162
Vesiclepedia VP_84162
Entrez Gene 84162
HGNC 26953
MIM 611565
UniProt Q2LD37  
 KIAA1109 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for KIAA1109
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylethanolamine transfer activity GO:1904121 ISS
Biological Process
    regulation of cell growth GO:0001558 NAS
    phagocytosis GO:0006909 IMP
    phospholipid transport GO:0015914 IEA
    endosomal transport GO:0016197 IMP
    regulation of epithelial cell differentiation GO:0030856 NAS
    endocytic recycling GO:0032456 IMP
    synaptic vesicle endocytosis GO:0048488 IBA
    intermembrane lipid transfer GO:0120009 ISS
Subcellular Localization
    nucleus GO:0005634 NAS
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 NAS
    mitochondrial membrane GO:0031966 IEA
    presynapse GO:0098793 IEA
    endoplasmic reticulum-plasma membrane contact site GO:0140268 ISS
 Experiment description of studies that identified KIAA1109 in sEVs
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for KIAA1109
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SSB 6741
Cross-Linking-MS (XL-MS) Homo sapiens
2 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
3 BUB3 9184
Affinity Capture-MS Homo sapiens
4 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
5 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
6 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
7 EFNA4  
Affinity Capture-MS Homo sapiens
8 C1orf43 25912
Affinity Capture-MS Homo sapiens
9 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
10 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
11 CCDC28A  
Affinity Capture-MS Homo sapiens
12 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
13 ZNF131  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KIAA1109 is involved
No pathways found





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