Gene description for GDF2
Gene name growth differentiation factor 2
Gene symbol GDF2
Other names/aliases BMP-9
BMP9
HHT5
Species Homo sapiens
 Database cross references - GDF2
ExoCarta ExoCarta_2658
Entrez Gene 2658
HGNC 4217
MIM 605120
UniProt Q9UK05  
 GDF2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GDF2
Molecular Function
    transforming growth factor beta receptor binding GO:0005160 IBA
    protein binding GO:0005515 IPI
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    blood vessel morphogenesis GO:0048514 IDA
    positive regulation of angiogenesis GO:0045766 IDA
    negative regulation of angiogenesis GO:0016525 TAS
    positive regulation of osteoblast differentiation GO:0045669 IEA
    positive regulation of BMP signaling pathway GO:0030513 IEA
    ossification GO:0001503 TAS
    positive regulation of endothelial cell proliferation GO:0001938 IDA
    cartilage development GO:0051216 TAS
    cellular response to BMP stimulus GO:0071773 IDA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA
    positive regulation of interleukin-8 production GO:0032757 IDA
    BMP signaling pathway GO:0030509 IDA
    cellular iron ion homeostasis GO:0006879 TAS
    regulation of apoptotic process GO:0042981 IBA
    negative regulation of DNA replication GO:0008156 TAS
    vasculogenesis GO:0001570 IEA
    negative regulation of endothelial cell proliferation GO:0001937 IDA
    regulation of MAPK cascade GO:0043408 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of blood vessel endothelial cell migration GO:0043537 TAS
    pathway-restricted SMAD protein phosphorylation GO:0060389 IDA
    patterning of blood vessels GO:0001569 IDA
    positive regulation of endothelial cell differentiation GO:0045603 IEA
    osteoblast differentiation GO:0001649 IEA
    activin receptor signaling pathway GO:0032924 IDA
    negative regulation of endothelial cell migration GO:0010596 IDA
    angiogenesis GO:0001525 IMP
    growth GO:0040007 IEA
    negative regulation of cell growth GO:0030308 IDA
    negative regulation of DNA biosynthetic process GO:2000279 IDA
    cell development GO:0048468 IBA
    SMAD protein signal transduction GO:0060395 IBA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cell GO:0005623 TAS
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified GDF2 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GDF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GDF2 is involved
No pathways found





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