Gene description for ACVRL1
Gene name activin A receptor type II-like 1
Gene symbol ACVRL1
Other names/aliases ACVRLK1
ALK-1
ALK1
HHT
HHT2
ORW2
SKR3
TSR-I
Species Homo sapiens
 Database cross references - ACVRL1
ExoCarta ExoCarta_94
Vesiclepedia VP_94
Entrez Gene 94
HGNC 175
MIM 601284
UniProt P37023  
 ACVRL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ACVRL1
Molecular Function
    transforming growth factor beta binding GO:0050431 IPI
    activin binding GO:0048185 IDA
    receptor signaling protein serine/threonine kinase activity GO:0004702 IEA
    ATP binding GO:0005524 IDA
    protein kinase binding GO:0019901 IPI
    activin receptor activity, type I GO:0016361 TAS
    transforming growth factor beta-activated receptor activity GO:0005024 IDA
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 NAS
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activity GO:0004674 IDA
    metal ion binding GO:0046872 IEA
    SMAD binding GO:0046332 IDA
    transforming growth factor beta receptor activity, type I GO:0005025 IDA
Biological Process
    positive regulation of angiogenesis GO:0045766 IEA
    negative regulation of cell proliferation GO:0008285 IMP
    negative regulation of cell migration GO:0030336 IMP
    protein heterooligomerization GO:0051291 IEA
    negative regulation of endothelial cell migration GO:0010596 IDA
    protein phosphorylation GO:0006468 IDA
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 TAS
    signal transduction by protein phosphorylation GO:0023014 IEA
    lymphangiogenesis GO:0001946 ISS
    lymphatic endothelial cell differentiation GO:0060836 IMP
    in utero embryonic development GO:0001701 IEA
    cellular response to BMP stimulus GO:0071773 IMP
    blood vessel remodeling GO:0001974 ISS
    venous blood vessel development GO:0060841 ISS
    positive regulation of BMP signaling pathway GO:0030513 IDA
    negative regulation of cell growth GO:0030308 IDA
    regulation of endothelial cell proliferation GO:0001936 TAS
    signal transduction GO:0007165 IDA
    artery development GO:0060840 ISS
    negative regulation of blood vessel endothelial cell migration GO:0043537 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    endothelial tube morphogenesis GO:0061154 IMP
    negative regulation of cell adhesion GO:0007162 IMP
    BMP signaling pathway GO:0030509 IMP
    positive regulation of chondrocyte differentiation GO:0032332 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    blood circulation GO:0008015 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of endothelial cell proliferation GO:0001937 IEA
    negative regulation of endothelial cell differentiation GO:0045602 IEA
    blood vessel maturation GO:0001955 TAS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IMP
    regulation of blood vessel endothelial cell migration GO:0043535 TAS
    positive regulation of endothelial cell differentiation GO:0045603 IEA
    positive regulation of endothelial cell proliferation GO:0001938 IEA
    retina vasculature development in camera-type eye GO:0061298 ISS
    angiogenesis GO:0001525 IMP
    regulation of DNA replication GO:0006275 TAS
    activin receptor signaling pathway GO:0032924 IDA
    negative regulation of focal adhesion assembly GO:0051895 IMP
    regulation of transcription, DNA-templated GO:0006355 IMP
    negative regulation of DNA biosynthetic process GO:2000279 IMP
    regulation of blood pressure GO:0008217 IMP
    wound healing, spreading of epidermal cells GO:0035313 IMP
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IDA
    neuronal cell body GO:0043025 IEA
    dendrite GO:0030425 IEA
    cell surface GO:0009986 IDA
 Experiment description of studies that identified ACVRL1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ACVRL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFBRAP1 9392
Invivo Homo sapiens
2 TGFBR2 7048
Invivo Homo sapiens
3 TGFB1 7040
Invivo Homo sapiens
4 SNX6 58533
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which ACVRL1 is involved
No pathways found





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