Gene description for Stx8
Gene name syntaxin 8
Gene symbol Stx8
Other names/aliases 0610007H08Rik
1110002H11Rik
4930571E13Rik
CARB
Species Mus musculus
 Database cross references - Stx8
ExoCarta ExoCarta_55943
Entrez Gene 55943
UniProt O88983  
 Stx8 identified in exosomes derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Stx8
Molecular Function
    syntaxin binding GO:0019905 ISO
    chloride channel inhibitor activity GO:0019869 ISO
    ubiquitin protein ligase binding GO:0031625 IPI
    SNARE binding GO:0000149 ISO
    SNAP receptor activity GO:0005484 IBA
Biological Process
    early endosome to late endosome transport GO:0045022 ISO
    regulation of protein localization to plasma membrane GO:1903076 ISO
    intracellular protein transport GO:0006886 IBA
    endosome to lysosome transport GO:0008333 ISO
    vesicle fusion GO:0006906 ISO
    transport GO:0006810 IEA
    vesicle-mediated transport GO:0016192 ISO
Subcellular Localization
    vesicle GO:0031982 ISO
    early endosome GO:0005769 ISO
    endosome GO:0005768 ISO
    recycling endosome GO:0055037 ISO
    trans-Golgi network GO:0005802 ISO
    lysosomal membrane GO:0005765 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IBA
    late endosome membrane GO:0031902 ISO
    SNARE complex GO:0031201 ISO
    late endosome GO:0005770 ISO
 Experiment description of studies that identified Stx8 in exosomes
1
Experiment ID 14
ISEV standards
✔
EM
EV Biophysical techniques
✔
RAB7|RAB11
EV Cytosolic markers
✔
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
✔
DNM
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Stx8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACVR1 90
Affinity Capture-Luminescence Homo sapiens
2 TGFBR1  
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml
 Pathways in which Stx8 is involved
No pathways found





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