Gene description for FBN3
Gene name fibrillin 3
Gene symbol FBN3
Other names/aliases -
Species Homo sapiens
 Database cross references - FBN3
ExoCarta ExoCarta_84467
Entrez Gene 84467
HGNC 18794
MIM 608529
UniProt Q75N90  
 FBN3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FBN3
Molecular Function
    calcium ion binding GO:0005509 IEA
    extracellular matrix structural constituent GO:0005201 IBA
Biological Process
    anatomical structure morphogenesis GO:0009653 IBA
    regulation of cellular response to growth factor stimulus GO:0090287 IBA
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular matrix GO:0031012 IBA
 Experiment description of studies that identified FBN3 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FBN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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