Gene description for FRMD5
Gene name FERM domain containing 5
Gene symbol FRMD5
Other names/aliases -
Species Homo sapiens
 Database cross references - FRMD5
ExoCarta ExoCarta_84978
Entrez Gene 84978
HGNC 28214
MIM 616309
UniProt Q7Z6J6  
 FRMD5 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FRMD5
Molecular Function
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 IEA
Biological Process
    biological_process GO:0008150 ND
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cellular_component GO:0005575 ND
    cytoskeleton GO:0005856 IEA
    extrinsic component of membrane GO:0019898 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified FRMD5 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FRMD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FRMD5 is involved
No pathways found





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