Gene description for SNX10
Gene name sorting nexin 10
Gene symbol SNX10
Other names/aliases OPTB8
Species Homo sapiens
 Database cross references - SNX10
ExoCarta ExoCarta_29887
Entrez Gene 29887
HGNC 14974
MIM 614780
UniProt Q9Y5X0  
 SNX10 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SNX10
Molecular Function
    1-phosphatidylinositol binding GO:0005545 IMP
    protein binding GO:0005515 IPI
    ATPase binding GO:0051117 IPI
Biological Process
    vesicle organization GO:0016050 IBA
    osteoclast differentiation GO:0030316 ISS
    endocytosis GO:0006897 IBA
    protein localization to cilium GO:0061512 IMP
    endosome organization GO:0007032 IMP
    cilium assembly GO:0042384 IMP
    protein localization to centrosome GO:0071539 IMP
    protein transport GO:0015031 IEA
Subcellular Localization
    endosome GO:0005768 IBA
    extrinsic component of endosome membrane GO:0031313 IDA
    centrosome GO:0005813 IDA
    endoplasmic reticulum GO:0005783 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified SNX10 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SNX10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SNX10 is involved
No pathways found





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