Gene description for ADGRL3
Gene name adhesion G protein-coupled receptor L3
Gene symbol ADGRL3
Other names/aliases CIRL3
LEC3
LPHN3
Species Homo sapiens
 Database cross references - ADGRL3
ExoCarta ExoCarta_23284
Vesiclepedia VP_23284
Entrez Gene 23284
HGNC 20974
UniProt Q9HAR2  
 ADGRL3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ADGRL3
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    G protein-coupled receptor activity GO:0004930 NAS
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
Biological Process
    neuron migration GO:0001764 ISS
    cell surface receptor signaling pathway GO:0007166 IEA
    G protein-coupled receptor signaling pathway GO:0007186 NAS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    synapse assembly GO:0007416 IBA
    synapse assembly GO:0007416 ISS
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IBA
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IBA
    cell-cell junction GO:0005911 ISS
    membrane GO:0016020 NAS
    axon GO:0030424 IBA
    axon GO:0030424 ISS
    glutamatergic synapse GO:0098978 IBA
 Experiment description of studies that identified ADGRL3 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADGRL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MARCH1  
Affinity Capture-MS Homo sapiens
3 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SUN3  
Affinity Capture-MS Homo sapiens
5 CLEC2D  
Affinity Capture-MS Homo sapiens
6 TMEM169  
Affinity Capture-MS Homo sapiens
7 MMP26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ASGR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MPL 4352
Affinity Capture-MS Homo sapiens
10 SLC22A4 6583
Affinity Capture-MS Homo sapiens
11 GP5 2814
Affinity Capture-MS Homo sapiens
12 LGALS1 3956
Affinity Capture-MS Homo sapiens
13 TMEM9 252839
Affinity Capture-MS Homo sapiens
14 KRTCAP3 200634
Affinity Capture-MS Homo sapiens
15 ATP1B1 481
Affinity Capture-MS Homo sapiens
16 HYPM  
Affinity Capture-MS Homo sapiens
17 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 YIPF3 25844
Affinity Capture-MS Homo sapiens
19 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADGRL3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here