Gene description for TBC1D8B
Gene name TBC1 domain family, member 8B (with GRAM domain)
Gene symbol TBC1D8B
Other names/aliases -
Species Homo sapiens
 Database cross references - TBC1D8B
ExoCarta ExoCarta_54885
Entrez Gene 54885
HGNC 24715
UniProt Q0IIM8  
 TBC1D8B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TBC1D8B
Molecular Function
    GTPase activator activity GO:0005096 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
 Experiment description of studies that identified TBC1D8B in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TBC1D8B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TBC1D8B is involved
PathwayEvidenceSource
Golgi Associated Vesicle Biogenesis TAS Reactome





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