Gene description for ABCC5
Gene name ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Gene symbol ABCC5
Other names/aliases ABC33
EST277145
MOAT-C
MOATC
MRP5
SMRP
pABC11
Species Homo sapiens
 Database cross references - ABCC5
ExoCarta ExoCarta_10057
Entrez Gene 10057
HGNC 56
MIM 605251
UniProt O15440  
 ABCC5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ABCC5
Molecular Function
    organic anion transmembrane transporter activity GO:0008514 IEA
    ATP binding GO:0005524 IEA
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    hyaluronan metabolic process GO:0030212 TAS
    organic anion transport GO:0015711 IEA
    hyaluronan biosynthetic process GO:0030213 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    transport GO:0006810 TAS
    transmembrane transport GO:0055085 TAS
    carbohydrate metabolic process GO:0005975 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified ABCC5 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ABCC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ABCC5 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport TAS Reactome
Hyaluronan biosynthesis and export TAS Reactome





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