Gene description for MEX3C
Gene name mex-3 RNA binding family member C
Gene symbol MEX3C
Other names/aliases BM-013
MEX-3C
RKHD2
RNF194
Species Homo sapiens
 Database cross references - MEX3C
ExoCarta ExoCarta_51320
Vesiclepedia VP_51320
Entrez Gene 51320
HGNC 28040
MIM 611005
UniProt Q5U5Q3  
 MEX3C identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MEX3C
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    chondrocyte hypertrophy GO:0003415 IEA
    regulation of fat cell differentiation GO:0045598 IEA
    energy homeostasis GO:0097009 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified MEX3C in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MEX3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 ZNF574  
Affinity Capture-MS Homo sapiens
3 EIF3A 8661
Affinity Capture-MS Homo sapiens
4 MARK3 4140
Affinity Capture-MS Homo sapiens
5 CNOT7 29883
Affinity Capture-Western Homo sapiens
6 UBE2S  
Affinity Capture-Western Homo sapiens
7 BMS1  
Affinity Capture-MS Homo sapiens
8 HSPA5 3309
Affinity Capture-MS Homo sapiens
9 AP2B1 163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 USP7 7874
Affinity Capture-Western Homo sapiens
11 WDR6 11180
Affinity Capture-MS Homo sapiens
12 UBE2N 7334
Affinity Capture-Western Homo sapiens
13 STUB1 10273
Affinity Capture-MS Homo sapiens
14 ILF3 3609
Affinity Capture-MS Homo sapiens
15 AIFM1 9131
Affinity Capture-MS Homo sapiens
16 POLRMT 5442
Affinity Capture-MS Homo sapiens
17 RBM19 9904
Affinity Capture-MS Homo sapiens
18 XPO1 7514
Affinity Capture-MS Homo sapiens
19 PIP 5304
Affinity Capture-MS Homo sapiens
20 PPIE 10450
Affinity Capture-MS Homo sapiens
21 LINC00839  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
22 UBE2V1 7335
Affinity Capture-Western Homo sapiens
23 GLE1 2733
Affinity Capture-MS Homo sapiens
24 MRPS30 10884
Affinity Capture-MS Homo sapiens
25 YWHAE 7531
Affinity Capture-MS Homo sapiens
26 UBE2L3 7332
Reconstituted Complex Homo sapiens
27 PRPF6 24148
Affinity Capture-MS Homo sapiens
28 NUFIP2 57532
Affinity Capture-MS Homo sapiens
29 AP2A2 161
Affinity Capture-MS Homo sapiens
30 FBXO45 200933
Affinity Capture-MS Homo sapiens
31 PAN2  
Affinity Capture-Western Homo sapiens
32 CUL3 8452
Affinity Capture-MS Homo sapiens
33 PTEN 5728
Affinity Capture-MS Homo sapiens
34 GTPBP1 9567
Affinity Capture-MS Homo sapiens
35 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
36 CCAR2 57805
Affinity Capture-MS Homo sapiens
37 MTHFD1 4522
Affinity Capture-MS Homo sapiens
38 DHX37  
Affinity Capture-MS Homo sapiens
39 DDX58 23586
Affinity Capture-Western Homo sapiens
40 SOX2  
Affinity Capture-MS Homo sapiens
41 MYO1C 4641
Affinity Capture-MS Homo sapiens
42 NXF1 10482
Affinity Capture-MS Homo sapiens
43 ATAD3A 55210
Affinity Capture-MS Homo sapiens
44 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
45 LRPPRC 10128
Affinity Capture-MS Homo sapiens
46 LMO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 GIGYF2 26058
Affinity Capture-MS Homo sapiens
48 UBE2D2 7322
Reconstituted Complex Homo sapiens
49 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PCBP1 5093
Affinity Capture-MS Homo sapiens
51 PABPC1 26986
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
52 MYCBP2 23077
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PRPF19 27339
Affinity Capture-MS Homo sapiens
54 CNOT1 23019
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
55 SAFB2 9667
Affinity Capture-MS Homo sapiens
56 CAD 790
Affinity Capture-MS Homo sapiens
57 ATXN2L 11273
Affinity Capture-MS Homo sapiens
58 MEX3B 84206
Affinity Capture-MS Homo sapiens
59 AP2A1 160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 PRPF8 10594
Affinity Capture-MS Homo sapiens
61 CNOT3 4849
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
62 MEX3D  
Affinity Capture-MS Homo sapiens
63 TRIM28 10155
Affinity Capture-MS Homo sapiens
64 HLA-A 3105
Protein-RNA Homo sapiens
65 ADAR 103
Affinity Capture-MS Homo sapiens
66 NOL6 65083
Affinity Capture-MS Homo sapiens
67 LENG8  
Affinity Capture-MS Homo sapiens
68 UBA1 7317
Affinity Capture-Western Homo sapiens
69 PRKDC 5591
Affinity Capture-MS Homo sapiens
70 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
71 EEF1A1 1915
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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