Gene description for DNAH7
Gene name dynein, axonemal, heavy chain 7
Gene symbol DNAH7
Other names/aliases -
Species Homo sapiens
 Database cross references - DNAH7
ExoCarta ExoCarta_56171
Vesiclepedia VP_56171
Entrez Gene 56171
HGNC 18661
MIM 610061
UniProt Q8WXX0  
 DNAH7 identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
Thymus 23844026    
 Gene ontology annotations for DNAH7
Molecular Function
    microtubule motor activity GO:0003777 IC
    microtubule motor activity GO:0003777 NAS
    calcium ion binding GO:0005509 IEA
    ATP binding GO:0005524 IEA
    minus-end-directed microtubule motor activity GO:0008569 IBA
    ATP hydrolysis activity GO:0016887 IEA
    dynein intermediate chain binding GO:0045505 IBA
    dynein light intermediate chain binding GO:0051959 IBA
Biological Process
    cilium movement GO:0003341 IMP
    inner dynein arm assembly GO:0036159 IMP
    cilium-dependent cell motility GO:0060285 NAS
    cilium movement involved in cell motility GO:0060294 IBA
Subcellular Localization
    cytosol GO:0005829 IDA
    axonemal dynein complex GO:0005858 NAS
    microtubule GO:0005874 IEA
    cilium GO:0005929 IDA
    inner dynein arm GO:0036156 IBA
    inner dynein arm GO:0036156 IMP
    9+2 motile cilium GO:0097729 IBA
 Experiment description of studies that identified DNAH7 in exosomes
1
Experiment ID 44
MISEV standards
IEM
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNAH7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DYNC1I2 1781
Proximity Label-MS Homo sapiens
2 STARD7 56910
Affinity Capture-MS Homo sapiens
3 UBC 7316
Reconstituted Complex Homo sapiens
4 EGFR 1956
Affinity Capture-MS Homo sapiens
5 NR3C1 2908
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DNAH7 is involved
No pathways found





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