Gene description for Dlg2
Gene name discs, large homolog 2 (Drosophila)
Gene symbol Dlg2
Other names/aliases A330103J02Rik
B230218P12Rik
B330007M19Rik
Dlgh2
Gm1197
PSD93
Species Mus musculus
 Database cross references - Dlg2
ExoCarta ExoCarta_23859
Entrez Gene 23859
UniProt Q91XM9  
 Dlg2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dlg2
Molecular Function
    protein binding GO:0005515 IPI
    protein C-terminus binding GO:0008022 ISO
    protein heterodimerization activity GO:0046982 ISO
    kinase binding GO:0019900 ISO
    PDZ domain binding GO:0030165 ISO
    ionotropic glutamate receptor binding GO:0035255 IBA
    protein phosphatase binding GO:0019903 ISO
    guanylate kinase activity GO:0004385 IBA
Biological Process
    receptor clustering GO:0043113 ISO
    synaptic transmission GO:0007268 IMP
    nervous system development GO:0007399 IBA
    receptor localization to synapse GO:0097120 IBA
    sensory perception of pain GO:0019233 IMP
    negative regulation of phosphatase activity GO:0010923 ISO
    nucleotide phosphorylation GO:0046939 IBA
    neuronal ion channel clustering GO:0045161 ISO
Subcellular Localization
    neuronal cell body GO:0043025 ISO
    cell junction GO:0030054 IDA
    membrane GO:0016020 ISO
    synapse GO:0045202 IEA
    juxtaparanode region of axon GO:0044224 ISO
    postsynaptic membrane GO:0045211 IDA
    dendrite GO:0030425 ISO
    neuronal postsynaptic density GO:0097481 IDA
    cytoplasm GO:0005737 ISO
    ionotropic glutamate receptor complex GO:0008328 IBA
    voltage-gated potassium channel complex GO:0008076 ISO
    plasma membrane GO:0005886 IEA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified Dlg2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dlg2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dlg2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here