Gene description for Camk2b
Gene name calcium/calmodulin-dependent protein kinase II, beta
Gene symbol Camk2b
Other names/aliases -
Species Mus musculus
 Database cross references - Camk2b
ExoCarta ExoCarta_12323
Vesiclepedia VP_12323
Entrez Gene 12323
UniProt P28652  
 Camk2b identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Camk2b
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 IMP
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IDA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 ISO
    calcium/calmodulin-dependent protein kinase activity GO:0004683 ISS
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 IEA
    calcium-dependent protein serine/threonine kinase activity GO:0009931 ISO
    protein kinase binding GO:0019901 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    phospholipase binding GO:0043274 ISO
    structural constituent of postsynaptic actin cytoskeleton GO:0098973 ISO
    protein serine kinase activity GO:0106310 IEA
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IMP
    inhibitory G protein-coupled receptor phosphorylation GO:0002030 IDA
    calcium ion transport GO:0006816 IMP
    nervous system development GO:0007399 IEA
    positive regulation of neuron projection development GO:0010976 ISO
    positive regulation of neuron projection development GO:0010976 ISS
    peptidyl-serine phosphorylation GO:0018105 IDA
    cell differentiation GO:0030154 IEA
    regulation of synaptic transmission, cholinergic GO:0032222 IMP
    response to cadmium ion GO:0046686 IDA
    protein autophosphorylation GO:0046777 IMP
    protein autophosphorylation GO:0046777 ISO
    regulation of neuronal synaptic plasticity GO:0048168 IBA
    regulation of long-term neuronal synaptic plasticity GO:0048169 IMP
    cell projection morphogenesis GO:0048858 ISO
    neuromuscular process controlling balance GO:0050885 IMP
    long-term synaptic potentiation GO:0060291 ISO
    activation of meiosis involved in egg activation GO:0060466 IMP
    positive regulation of dendritic spine morphogenesis GO:0061003 ISO
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    regulation of synapse maturation GO:0090128 ISO
    positive regulation of synapse maturation GO:0090129 ISO
    positive regulation of synapse maturation GO:0090129 ISS
    apoptotic signaling pathway GO:0097190 IDA
    regulation of protein localization to plasma membrane GO:1903076 IBA
    regulation of protein localization to plasma membrane GO:1903076 ISO
    regulation of neuron migration GO:2001222 IMP
    regulation of neuron migration GO:2001222 ISO
    positive regulation of apoptotic signaling pathway GO:2001235 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    calcium- and calmodulin-dependent protein kinase complex GO:0005954 ISO
    postsynaptic density GO:0014069 IBA
    postsynaptic density GO:0014069 IDA
    postsynaptic density GO:0014069 ISO
    dendrite GO:0030425 ISO
    sarcoplasmic reticulum membrane GO:0033017 IEA
    neuron projection GO:0043005 IBA
    perikaryon GO:0043204 ISO
    spindle midzone GO:0051233 IDA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Camk2b in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Camk2b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fxr1 14359
Affinity Capture-MS Mus musculus
2 Tnik  
Affinity Capture-MS Mus musculus
3 SNCA 6622
Affinity Capture-MS Homo sapiens
4 Hcn1  
Affinity Capture-MS Mus musculus
5 Cnksr2  
Affinity Capture-MS Mus musculus
6 Cyfip2 76884
Affinity Capture-MS Mus musculus
7 Pde4dip  
Affinity Capture-MS Mus musculus
8 Kalrn  
Affinity Capture-MS Mus musculus
9 Inadl  
Affinity Capture-MS Mus musculus
10 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
11 Syngap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
12 Fmr1  
Affinity Capture-MS Mus musculus
13 Kctd13  
Affinity Capture-MS Mus musculus
14 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
15 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
16 Huwe1  
Affinity Capture-MS Mus musculus
17 Mecp2  
Affinity Capture-MS Mus musculus
18 Ywhaz 22631
Affinity Capture-MS Mus musculus
19 Fzr1  
Affinity Capture-MS Mus musculus
20 Grin2b  
Affinity Capture-Western Mus musculus
21 Mycbp2 105689
Affinity Capture-MS Mus musculus
22 Cyfip1 20430
Affinity Capture-MS Mus musculus
23 Agap2  
Affinity Capture-MS Mus musculus
24 Grin1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
25 Tsc1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here