Gene description for Synj1
Gene name synaptojanin 1
Gene symbol Synj1
Other names/aliases A930006D20Rik
AA675315
mKIAA0910
Species Mus musculus
 Database cross references - Synj1
ExoCarta ExoCarta_104015
Entrez Gene 104015
 Synj1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Synj1
Molecular Function
    protein complex binding GO:0032403 ISO
    protein C-terminus binding GO:0008022 ISO
    phosphatidylinositol phosphate 5-phosphatase activity GO:0034595 ISO
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IMP
    SH3 domain binding GO:0017124 ISO
Biological Process
    inositol phosphate dephosphorylation GO:0046855 IMP
    synaptic vesicle uncoating GO:0016191 IMP
    synaptic vesicle priming GO:0016082 IMP
    neurotransmitter transport GO:0006836 IMP
    phosphatidylinositol dephosphorylation GO:0046856 IMP
    synaptic vesicle transport GO:0048489 IMP
    positive regulation of receptor-mediated endocytosis GO:0048260 ISO
    positive regulation of gliogenesis GO:0014015 ISO
    positive regulation of synaptic vesicle recycling GO:1903423 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    learning GO:0007612 IMP
    response to retinoic acid GO:0032526 ISO
    response to cytokine GO:0034097 ISO
    phosphatidylinositol metabolic process GO:0046488 TAS
    dephosphorylation GO:0016311 ISO
    synaptic vesicle endocytosis GO:0048488 IMP
Subcellular Localization
    membrane coat GO:0030117 IDA
    clathrin coat GO:0030118 TAS
    cytoplasm GO:0005737 ISO
    protein complex GO:0043234 ISO
    neuron projection GO:0043005 ISO
    cell GO:0005623 IMP
 Experiment description of studies that identified Synj1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Synj1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Synj1 is involved
No pathways found





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