Gene description for App
Gene name	amyloid beta (A4) precursor protein
Gene symbol	App
Other names/aliases	Abeta Abpp Adap Ag Cvap E030013M08Rik betaApp
Species	Mus musculus
Database cross references - App
ExoCarta	ExoCarta_11820
Entrez Gene	11820
UniProt	P12023
App identified in exosomes derived from the following tissue/cell type
Fibroblasts	23260141
Mast cells	17486113

Gene ontology annotations for App

Molecular Function     serine-type endopeptidase inhibitor activity GO:0004867 ISO     peptidase inhibitor activity GO:0030414 IEA     DNA binding GO:0003677 IDA     enzyme binding GO:0019899 ISO     peptidase activator activity GO:0016504 ISO     protein binding GO:0005515 IPI     receptor binding GO:0005102 ISO     growth factor receptor binding GO:0070851 ISO     identical protein binding GO:0042802 ISO     metal ion binding GO:0046872 IEA     PTB domain binding GO:0051425 ISO     acetylcholine receptor binding GO:0033130 ISO     heparin binding GO:0008201 IEA     transition metal ion binding GO:0046914 IEA Biological Process     axonogenesis GO:0007409 IMP     endocytosis GO:0006897 IMP     locomotory behavior GO:0007626 IGI     neuron remodeling GO:0016322 IMP     positive regulation of mitotic cell cycle GO:0045931 IMP     Notch signaling pathway GO:0007219 IEA     synaptic growth at neuromuscular junction GO:0051124 IGI     regulation of translation GO:0006417 IDA     forebrain development GO:0030900 IMP     negative regulation of neuron differentiation GO:0045665 IGI     negative regulation of endopeptidase activity GO:0010951 ISO     regulation of synapse structure or activity GO:0050803 IMP     visual learning GO:0008542 IMP     protein homooligomerization GO:0051260 ISO     neuron apoptotic process GO:0051402 ISO     negative regulation of peptidase activity GO:0010466 IEA     mRNA polyadenylation GO:0006378 IDA     collateral sprouting in absence of injury GO:0048669 IGI     extracellular matrix organization GO:0030198 IGI     dendrite development GO:0016358 IMP     regulation of multicellular organism growth GO:0040014 IMP     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI     mating behavior GO:0007617 IGI     adult locomotory behavior GO:0008344 IMP     protein phosphorylation GO:0006468 IMP     apoptotic process GO:0006915 IEA     axon cargo transport GO:0008088 IMP     cholesterol metabolic process GO:0008203 IMP     neuron projection development GO:0031175 IDA     nervous system development GO:0007399 IEA     regulation of gene expression GO:0010468 IDA     axon midline choice point recognition GO:0016199 IMP     cellular copper ion homeostasis GO:0006878 IMP     regulation of protein binding GO:0043393 IMP     positive regulation of peptidase activity GO:0010952 ISO     neuromuscular process controlling balance GO:0050885 IGI     smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 IGI     ionotropic glutamate receptor signaling pathway GO:0035235 IMP     positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IMP     response to oxidative stress GO:0006979 IGI     suckling behavior GO:0001967 IGI     regulation of epidermal growth factor-activated receptor activity GO:0007176 IGI     cell adhesion GO:0007155 IEA Subcellular Localization     cytoplasm GO:0005737 ISO     extracellular space GO:0005615 ISO     ER to Golgi transport vesicle GO:0030134 IDA     intracellular membrane-bounded organelle GO:0043231 ISO     neuromuscular junction GO:0031594 IDA     spindle midzone GO:0051233 IDA     membrane raft GO:0045121 ISO     ciliary rootlet GO:0035253 IDA     apical part of cell GO:0045177 IDA     cell GO:0005623 IGI     endosome GO:0005768 ISO     nuclear envelope lumen GO:0005641 ISO     intracellular GO:0005622 IGI     plasma membrane GO:0005886 ISO     neuron projection GO:0043005 ISO     cell surface GO:0009986 ISO     axon GO:0030424 ISO     terminal bouton GO:0043195 ISO     membrane GO:0016020 TAS     integral component of membrane GO:0016021 IDA     smooth endoplasmic reticulum GO:0005790 IGI     cell-cell junction GO:0005911 IDA     Golgi apparatus GO:0005794 ISO     perinuclear region of cytoplasm GO:0048471 ISO     receptor complex GO:0043235 ISO     cytoplasmic vesicle GO:0031410 IDA     coated pit GO:0005905 IEA     extracellular exosome GO:0070062 ISO