Gene description for Calr
Gene name	calreticulin
Gene symbol	Calr
Other names/aliases	CRT Calregulin
Species	Mus musculus
Database cross references - Calr
ExoCarta	ExoCarta_12317
Entrez Gene	12317
UniProt	P14211
Calr identified in exosomes derived from the following tissue/cell type
Brain cancer cells	19109410
Pancreatic cells	19351151

Gene ontology annotations for Calr

Molecular Function     unfolded protein binding GO:0051082 ISO     glycoprotein binding GO:0001948 ISO     hormone binding GO:0042562 ISO     androgen receptor binding GO:0050681 ISO     protein binding GO:0005515 IPI     carbohydrate binding GO:0030246 IDA     iron ion binding GO:0005506 ISO     metal ion binding GO:0046872 IEA     calcium ion binding GO:0005509 ISO     poly(A) RNA binding GO:0044822 ISO     ubiquitin protein ligase binding GO:0031625 ISO     mRNA binding GO:0003729 ISO     integrin binding GO:0005178 ISO     peptide binding GO:0042277 ISO Biological Process     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO     chaperone-mediated protein folding GO:0061077 ISO     peptide antigen assembly with MHC class I protein complex GO:0002502 IMP     negative regulation of retinoic acid receptor signaling pathway GO:0048387 ISO     positive regulation of DNA replication GO:0045740 ISO     positive regulation of cell proliferation GO:0008284 ISO     cell cycle arrest GO:0007050 ISO     regulation of meiotic nuclear division GO:0040020 IDA     positive regulation of phagocytosis GO:0050766 IMP     positive regulation of dendritic cell chemotaxis GO:2000510 ISO     protein stabilization GO:0050821 IDA     negative regulation of transcription, DNA-templated GO:0045892 ISO     negative regulation of translation GO:0017148 ISO     protein export from nucleus GO:0006611 ISO     negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 ISO     protein folding GO:0006457 IEA     positive regulation of cell cycle GO:0045787 ISO     protein localization to nucleus GO:0034504 ISO     positive regulation of gene expression GO:0010628 IMP     cellular senescence GO:0090398 ISO     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO     cortical actin cytoskeleton organization GO:0030866 IDA     negative regulation of neuron differentiation GO:0045665 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     nucleus GO:0005634 ISO     endoplasmic reticulum GO:0005783 ISS     smooth endoplasmic reticulum GO:0005790 ISO     intracellular membrane-bounded organelle GO:0043231 ISO     focal adhesion GO:0005925 ISO     extracellular exosome GO:0070062 ISO     Golgi apparatus GO:0005794 ISO     perinuclear region of cytoplasm GO:0048471 ISO     cytosol GO:0005829 ISO     acrosomal vesicle GO:0001669 ISO     sarcoplasmic reticulum GO:0016529 ISO     membrane GO:0016020 ISO     MHC class I peptide loading complex GO:0042824 IMP     cell surface GO:0009986 ISO     endoplasmic reticulum lumen GO:0005788 ISO     protein complex GO:0043234 ISO     extracellular space GO:0005615 ISO     extracellular matrix GO:0031012 ISO     polysome GO:0005844 IDA     external side of plasma membrane GO:0009897 IDA