Gene description for Aplp1
Gene name amyloid beta (A4) precursor-like protein 1
Gene symbol Aplp1
Other names/aliases -
Species Mus musculus
 Database cross references - Aplp1
ExoCarta ExoCarta_11803
Entrez Gene 11803
UniProt Q03157  
 Aplp1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Aplp1
Molecular Function
    alpha-2A adrenergic receptor binding GO:0031694 ISO
    alpha-2B adrenergic receptor binding GO:0031695 ISO
    transition metal ion binding GO:0046914 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
    alpha-2C adrenergic receptor binding GO:0031696 ISO
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
Biological Process
    apoptotic process GO:0006915 IEA
    cell adhesion GO:0007155 IEA
    mRNA polyadenylation GO:0006378 IDA
    regulation of translation GO:0006417 IDA
    cellular response to norepinephrine stimulus GO:0071874 ISO
    extracellular matrix organization GO:0030198 IGI
    forebrain development GO:0030900 IGI
    endocytosis GO:0006897 IEA
    negative regulation of cAMP biosynthetic process GO:0030818 ISO
Subcellular Localization
    integral component of membrane GO:0016021 TAS
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Aplp1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aplp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aplp1 is involved
No pathways found

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