Gene description for Aplp1
Gene name amyloid beta (A4) precursor-like protein 1
Gene symbol Aplp1
Other names/aliases -
Species Mus musculus
 Database cross references - Aplp1
ExoCarta ExoCarta_11803
Vesiclepedia VP_11803
Entrez Gene 11803
UniProt Q03157  
 Aplp1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Aplp1
Molecular Function
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IEA
    alpha-2A adrenergic receptor binding GO:0031694 IBA
    alpha-2A adrenergic receptor binding GO:0031694 IEA
    alpha-2A adrenergic receptor binding GO:0031694 ISO
    alpha-2B adrenergic receptor binding GO:0031695 IBA
    alpha-2B adrenergic receptor binding GO:0031695 IEA
    alpha-2B adrenergic receptor binding GO:0031695 ISO
    alpha-2C adrenergic receptor binding GO:0031696 IBA
    alpha-2C adrenergic receptor binding GO:0031696 IEA
    alpha-2C adrenergic receptor binding GO:0031696 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    transition metal ion binding GO:0046914 IEA
Biological Process
    regulation of translation GO:0006417 IDA
    endocytosis GO:0006897 IEA
    apoptotic process GO:0006915 IEA
    cell adhesion GO:0007155 IEA
    axonogenesis GO:0007409 IBA
    central nervous system development GO:0007417 IBA
    extracellular matrix organization GO:0030198 IGI
    forebrain development GO:0030900 IGI
    cellular response to norepinephrine stimulus GO:0071874 IEA
    cellular response to norepinephrine stimulus GO:0071874 ISO
    negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 IEA
    negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 ISO
    cytosolic mRNA polyadenylation GO:0180011 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Aplp1 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aplp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 App 11820
Affinity Capture-MS Mus musculus
2 Spon1 233744
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Aplp1 is involved
No pathways found





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