Gene description for Spon1
Gene name spondin 1, (f-spondin) extracellular matrix protein
Gene symbol Spon1
Other names/aliases AI666765
AW455831
BC020531
D330035F22Rik
FSP
Species Mus musculus
 Database cross references - Spon1
ExoCarta ExoCarta_233744
Entrez Gene 233744
UniProt Q8VCC9  
 Spon1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Spon1
Biological Process
    cell adhesion GO:0007155 IEA
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 ISO
    extracellular region GO:0005576 IEA
    proteinaceous extracellular matrix GO:0005578 IEA
 Experiment description of studies that identified Spon1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Spon1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Spon1 is involved
PathwayEvidenceSource
O-glycosylation of TSR domain-containing proteins IEA Reactome





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