Gene description for Ppib
Gene name peptidylprolyl isomerase B
Gene symbol Ppib
Other names/aliases AA408962
AA553318
AI844835
Cphn-2
Cphn2
CyP-20b
Species Mus musculus
 Database cross references - Ppib
ExoCarta ExoCarta_19035
Vesiclepedia VP_19035
Entrez Gene 19035
UniProt P24369  
 Ppib identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppib
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    RNA polymerase binding GO:0070063 ISO
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    peptide binding GO:0042277 IEA
    isomerase activity GO:0016853 IEA
Biological Process
    protein folding GO:0006457 IEA
    positive regulation of multicellular organism growth GO:0040018 ISO
    protein stabilization GO:0050821 ISO
    protein peptidyl-prolyl isomerization GO:0000413 IBA
    positive regulation by host of viral genome replication GO:0044829 ISO
    bone development GO:0060348 ISO
    positive regulation by host of viral process GO:0044794 ISO
Subcellular Localization
    endoplasmic reticulum chaperone complex GO:0034663 IDA
    extracellular exosome GO:0070062 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    endoplasmic reticulum GO:0005783 ISO
    membrane GO:0016020 ISO
    smooth endoplasmic reticulum GO:0005790 ISO
    nucleus GO:0005634 ISO
    focal adhesion GO:0005925 ISO
 Experiment description of studies that identified Ppib in exosomes
1
Experiment ID 907
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
MISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppib
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ppib is involved
PathwayEvidenceSource
Collagen biosynthesis and modifying enzymes IEA Reactome





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