Gene description for Aplp2
Gene name amyloid beta (A4) precursor-like protein 2
Gene symbol Aplp2
Other names/aliases AI790698
Species Mus musculus
 Database cross references - Aplp2
ExoCarta ExoCarta_11804
Entrez Gene 11804
UniProt Q06335  
 Aplp2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for Aplp2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    DNA binding GO:0003677 IEA
    transition metal ion binding GO:0046914 IEA
    heparin binding GO:0008201 IEA
Biological Process
    cholesterol metabolic process GO:0008203 IGI
    midbrain development GO:0030901 IGI
    locomotory behavior GO:0007626 IGI
    mating behavior GO:0007617 IGI
    suckling behavior GO:0001967 IGI
    extracellular matrix organization GO:0030198 IGI
    forebrain development GO:0030900 IGI
    neuromuscular process controlling balance GO:0050885 IGI
    cellular copper ion homeostasis GO:0006878 IMP
    regulation of epidermal growth factor-activated receptor activity GO:0007176 IGI
    embryo development GO:0009790 IGI
    regulation of protein binding GO:0043393 IGI
Subcellular Localization
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 IEA
    cell GO:0005623 IMP
    integral component of membrane GO:0016021 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Aplp2 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Aplp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aplp2 is involved
No pathways found

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