Gene description for Sparcl1
Gene name SPARC-like 1
Gene symbol Sparcl1
Other names/aliases Ecm2
Sc1
hevin
mast9
Species Mus musculus
 Database cross references - Sparcl1
ExoCarta ExoCarta_13602
Vesiclepedia VP_13602
Entrez Gene 13602
UniProt P70663  
 Sparcl1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Sparcl1
Molecular Function
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IEA
    collagen binding GO:0005518 IBA
    extracellular matrix binding GO:0050840 IBA
Biological Process
    signal transduction GO:0007165 IEA
    regulation of synapse organization GO:0050807 IBA
    regulation of synapse organization GO:0050807 ISO
    synaptic membrane adhesion GO:0099560 IDA
    synaptic membrane adhesion GO:0099560 IMP
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IEA
    collagen-containing extracellular matrix GO:0062023 IEA
    extracellular matrix of synaptic cleft GO:0098965 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Sparcl1 in exosomes
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sparcl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Prnp 19122
Affinity Capture-MS Mus musculus
Co-fractionation Mus musculus
2 Usp7  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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