Gene description for Pacs1
Gene name phosphofurin acidic cluster sorting protein 1
Gene symbol Pacs1
Other names/aliases AI325977
Species Mus musculus
 Database cross references - Pacs1
ExoCarta ExoCarta_107975
Entrez Gene 107975
UniProt Q8K212  
 Pacs1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pacs1
Molecular Function
    ion channel binding GO:0044325 ISO
Biological Process
    protein targeting to plasma membrane GO:0072661 ISO
    cellular protein localization GO:0034613 ISO
    protein targeting to Golgi GO:0000042 IDA
    positive regulation of protein binding GO:0032092 ISO
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    Golgi apparatus GO:0005794 IEA
    COPI-coated vesicle GO:0030137 IDA
 Experiment description of studies that identified Pacs1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pacs1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pacs1 is involved
No pathways found





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