Gene description for Zfhx3
Gene name zinc finger homeobox 3
Gene symbol Zfhx3
Other names/aliases A230102L03Rik
Atbf1
WBP9
mKIAA4228
Species Mus musculus
 Database cross references - Zfhx3
ExoCarta ExoCarta_11906
Entrez Gene 11906
 Zfhx3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zfhx3
Molecular Function
    nucleic acid binding GO:0003676 IEA
    transcription regulatory region DNA binding GO:0044212 ISO
    metal ion binding GO:0046872 IEA
    zinc ion binding GO:0008270 IEA
    DNA binding GO:0003677 IEA
    enzyme binding GO:0019899 ISO
    sequence-specific DNA binding GO:0043565 IEA
Biological Process
    muscle organ development GO:0007517 IEA
    positive regulation of myoblast differentiation GO:0045663 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of myoblast differentiation GO:0045662 ISO
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    transcription factor complex GO:0005667 ISO
    nucleolus GO:0005730 ISO
    mitochondrion GO:0005739 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Zfhx3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zfhx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Zfhx3 is involved
No pathways found





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