Gene description for Zfhx3
Gene name zinc finger homeobox 3
Gene symbol Zfhx3
Other names/aliases A230102L03Rik
Atbf1
WBP9
mKIAA4228
Species Mus musculus
 Database cross references - Zfhx3
ExoCarta ExoCarta_11906
Vesiclepedia VP_11906
Entrez Gene 11906
 Zfhx3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zfhx3
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IEA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    zinc ion binding GO:0008270 IEA
    enzyme binding GO:0019899 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    muscle organ development GO:0007517 IEA
    circadian regulation of gene expression GO:0032922 IMP
    negative regulation of myoblast differentiation GO:0045662 ISO
    positive regulation of myoblast differentiation GO:0045663 ISO
    regulation of neuron differentiation GO:0045664 IBA
    positive regulation of cell adhesion GO:0045785 IMP
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    response to transforming growth factor beta GO:0071559 ISO
    response to transforming growth factor beta GO:0071559 ISS
    regulation of locomotor rhythm GO:1904059 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    transcription regulator complex GO:0005667 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 HDA
    nuclear body GO:0016604 ISO
    nuclear body GO:0016604 ISS
 Experiment description of studies that identified Zfhx3 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zfhx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tfe3  
Affinity Capture-MS Mus musculus
2 Snap25 20614
Affinity Capture-MS Mus musculus
3 Epas1  
Co-fractionation Mus musculus
4 Pou5f1  
Affinity Capture-MS Mus musculus
5 Med23  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Zfhx3 is involved
No pathways found





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