Gene description for Sdc4
Gene name syndecan 4
Gene symbol Sdc4
Other names/aliases AA959608
AW108331
S4
Synd4
ryudocan
syndecan-4
Species Mus musculus
 Database cross references - Sdc4
ExoCarta ExoCarta_20971
Vesiclepedia VP_20971
Entrez Gene 20971
UniProt O35988  
 Sdc4 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Sdc4
Molecular Function
    fibronectin binding GO:0001968 IEA
    fibronectin binding GO:0001968 ISO
    protein kinase C binding GO:0005080 IEA
    protein kinase C binding GO:0005080 ISO
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    thrombospondin receptor activity GO:0070053 IEA
    thrombospondin receptor activity GO:0070053 ISO
Biological Process
    ureteric bud development GO:0001657 IEA
    neural tube closure GO:0001843 IGI
    regulation of fibroblast migration GO:0010762 IMP
    cell migration GO:0016477 IBA
    wound healing GO:0042060 IGI
    negative regulation of T cell proliferation GO:0042130 IEA
    negative regulation of T cell proliferation GO:0042130 ISO
    positive regulation of stress fiber assembly GO:0051496 IEA
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of focal adhesion assembly GO:0051894 IEA
    positive regulation of focal adhesion assembly GO:0051894 ISO
    inner ear receptor cell stereocilium organization GO:0060122 IGI
    positive regulation of exosomal secretion GO:1903543 IEA
    positive regulation of exosomal secretion GO:1903543 ISO
    positive regulation of extracellular exosome assembly GO:1903553 IEA
    positive regulation of extracellular exosome assembly GO:1903553 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    Golgi lumen GO:0005796 TAS
    focal adhesion GO:0005925 IEA
    focal adhesion GO:0005925 ISO
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IEA
    costamere GO:0043034 IEA
    costamere GO:0043034 ISO
 Experiment description of studies that identified Sdc4 in exosomes
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sdc4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sgta 52551
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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