Gene description for Sdc4
Gene name syndecan 4
Gene symbol Sdc4
Other names/aliases AA959608
Species Mus musculus
 Database cross references - Sdc4
ExoCarta ExoCarta_20971
Entrez Gene 20971
UniProt O35988  
 Sdc4 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Sdc4
Molecular Function
    protein kinase C binding GO:0005080 ISO
    fibronectin binding GO:0001968 ISO
    thrombospondin receptor activity GO:0070053 ISO
Biological Process
    inner ear receptor stereocilium organization GO:0060122 IGI
    regulation of fibroblast migration GO:0010762 IMP
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of extracellular exosome assembly GO:1903553 ISO
    neural tube closure GO:0001843 IGI
    positive regulation of exosomal secretion GO:1903543 ISO
    signal transduction GO:0007165 ISO
    cell migration GO:0016477 IBA
    wound healing GO:0042060 IGI
    positive regulation of focal adhesion assembly GO:0051894 ISO
    positive regulation of protein kinase activity GO:0045860 ISO
Subcellular Localization
    cell surface GO:0009986 ISO
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    integral component of membrane GO:0016021 IEA
    costamere GO:0043034 ISO
    extracellular region GO:0005576 IEA
    membrane GO:0016020 IEA
    membrane raft GO:0045121 ISO
 Experiment description of studies that identified Sdc4 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sdc4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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