Gene description for LYRM4
Gene name LYR motif containing 4
Gene symbol LYRM4
Other names/aliases C6orf149
CGI-203
COXPD19
ISD11
Species Homo sapiens
 Database cross references - LYRM4
ExoCarta ExoCarta_57128
Entrez Gene 57128
HGNC 21365
MIM 613311
UniProt Q9HD34  
 LYRM4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LYRM4
Biological Process
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified LYRM4 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LYRM4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LYRM4 is involved
PathwayEvidenceSource
Mitochondrial iron-sulfur cluster biogenesis TAS Reactome





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