Gene description for NUBPL
Gene name nucleotide binding protein-like
Gene symbol NUBPL
Other names/aliases C14orf127
IND1
huInd1
Species Homo sapiens
 Database cross references - NUBPL
ExoCarta ExoCarta_80224
Vesiclepedia VP_80224
Entrez Gene 80224
HGNC 20278
MIM 613621
UniProt Q8TB37  
 NUBPL identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NUBPL
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    4 iron, 4 sulfur cluster binding GO:0051539 IBA
    4 iron, 4 sulfur cluster binding GO:0051539 IDA
    ATP-dependent FeS chaperone activity GO:0140663 IEA
Biological Process
    mitochondrion organization GO:0007005 IMP
    iron-sulfur cluster assembly GO:0016226 IBA
    mitochondrial respiratory chain complex I assembly GO:0032981 IBA
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified NUBPL in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NUBPL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM9 252839
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 CS 1431
Proximity Label-MS Homo sapiens
4 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
5 C17orf80 55028
Proximity Label-MS Homo sapiens
6 PMPCB 9512
Proximity Label-MS Homo sapiens
7 NAAA  
Affinity Capture-MS Homo sapiens
8 TSFM 10102
Proximity Label-MS Homo sapiens
9 AUH 549
Proximity Label-MS Homo sapiens
10 DHCR24 1718
Affinity Capture-MS Homo sapiens
11 MRRF  
Proximity Label-MS Homo sapiens
12 MTIF2 4528
Proximity Label-MS Homo sapiens
13 KLK5 25818
Affinity Capture-MS Homo sapiens
14 LAMP3  
Affinity Capture-MS Homo sapiens
15 CLPP 8192
Proximity Label-MS Homo sapiens
16 BSG 682
Affinity Capture-MS Homo sapiens
17 ALPI  
Affinity Capture-MS Homo sapiens
18 TRUB2  
Proximity Label-MS Homo sapiens
19 MTG2  
Proximity Label-MS Homo sapiens
20 C6orf203  
Proximity Label-MS Homo sapiens
21 CUL3 8452
Affinity Capture-MS Homo sapiens
22 SDF2 6388
Affinity Capture-MS Homo sapiens
23 LOC254896  
Affinity Capture-MS Homo sapiens
24 SNX21  
Affinity Capture-MS Homo sapiens
25 TAF1  
Affinity Capture-MS Homo sapiens
26 ADAM7  
Affinity Capture-MS Homo sapiens
27 UFD1L 7353
Affinity Capture-MS Homo sapiens
28 VSIG4  
Affinity Capture-MS Homo sapiens
29 GZMH  
Affinity Capture-MS Homo sapiens
30 RPS27 6232
Affinity Capture-MS Homo sapiens
31 TMEM25  
Affinity Capture-MS Homo sapiens
32 GFM1 85476
Proximity Label-MS Homo sapiens
33 EPHA2 1969
Proximity Label-MS Homo sapiens
34 AARS2  
Proximity Label-MS Homo sapiens
35 SDF2L1 23753
Affinity Capture-MS Homo sapiens
36 IL12RB1  
Affinity Capture-MS Homo sapiens
37 PMPCA 23203
Proximity Label-MS Homo sapiens
38 GPR45  
Affinity Capture-MS Homo sapiens
39 ALDH3B2  
Affinity Capture-MS Homo sapiens
40 EXD2  
Proximity Label-MS Homo sapiens
41 TBRG4 9238
Proximity Label-MS Homo sapiens
42 ACAD9 28976
Proximity Label-MS Homo sapiens
43 GML  
Affinity Capture-MS Homo sapiens
44 KDM8  
Two-hybrid Homo sapiens
45 RNF2  
Affinity Capture-MS Homo sapiens
46 METTL17  
Proximity Label-MS Homo sapiens
47 MTUS2 23281
Two-hybrid Homo sapiens
48 DNAJB11 51726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SPCS3 60559
Affinity Capture-MS Homo sapiens
50 SP100 6672
Affinity Capture-MS Homo sapiens
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