Gene description for ECI2
Gene name enoyl-CoA delta isomerase 2
Gene symbol ECI2
Other names/aliases ACBD2
DRS-1
DRS1
HCA88
PECI
dJ1013A10.3
Species Homo sapiens
 Database cross references - ECI2
ExoCarta ExoCarta_10455
Vesiclepedia VP_10455
Entrez Gene 10455
HGNC 14601
MIM 608024
UniProt O75521  
 ECI2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ECI2
Molecular Function
    fatty-acyl-CoA binding GO:0000062 IEA
    delta(3)-delta(2)-enoyl-CoA isomerase activity GO:0004165 IBA
    delta(3)-delta(2)-enoyl-CoA isomerase activity GO:0004165 IDA
    protein binding GO:0005515 IPI
Biological Process
    fatty acid beta-oxidation GO:0006635 IEA
    fatty acid beta-oxidation GO:0006635 ISS
    fatty acid catabolic process GO:0009062 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    peroxisome GO:0005777 IBA
    peroxisome GO:0005777 IDA
    peroxisomal matrix GO:0005782 IDA
    peroxisomal matrix GO:0005782 TAS
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified ECI2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ECI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SF1 7536
Co-fractionation Homo sapiens
2 ZRANB1 54764
Affinity Capture-MS Homo sapiens
3 NEURL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ANLN 54443
Affinity Capture-MS Homo sapiens
5 CLPP 8192
Proximity Label-MS Homo sapiens
6 KDM1A 23028
Two-hybrid Homo sapiens
7 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
8 ECH1 1891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
10 PMPCB 9512
Proximity Label-MS Homo sapiens
11 TSFM 10102
Proximity Label-MS Homo sapiens
12 AUH 549
Proximity Label-MS Homo sapiens
13 MRPL11 65003
Proximity Label-MS Homo sapiens
14 UEVLD 55293
Co-fractionation Homo sapiens
15 BAG3 9531
Affinity Capture-MS Homo sapiens
16 TBRG4 9238
Proximity Label-MS Homo sapiens
17 Ndc80  
Affinity Capture-MS Mus musculus
18 IDE 3416
Affinity Capture-MS Homo sapiens
19 MTIF2 4528
Proximity Label-MS Homo sapiens
20 ZNF286A  
Affinity Capture-MS Homo sapiens
21 CIT 11113
Affinity Capture-MS Homo sapiens
22 UBE2H 7328
Affinity Capture-MS Homo sapiens
23 FBXL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 KANSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PRIMPOL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SCP2 6342
Co-fractionation Homo sapiens
27 CARTPT  
Affinity Capture-MS Homo sapiens
28 CD274 29126
Affinity Capture-MS Homo sapiens
29 PDHA1 5160
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
30 C6orf203  
Proximity Label-MS Homo sapiens
31 DBNL 28988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 UBE3A 7337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ACSS1  
Affinity Capture-MS Homo sapiens
34 MCCC1 56922
Affinity Capture-MS Homo sapiens
35 PPL 5493
Affinity Capture-MS Homo sapiens
36 MDH2 4191
Proximity Label-MS Homo sapiens
37 RDX 5962
Affinity Capture-MS Homo sapiens
38 GFM1 85476
Proximity Label-MS Homo sapiens
39 HSD17B13  
Affinity Capture-MS Homo sapiens
40 PMPCA 23203
Proximity Label-MS Homo sapiens
41 XPA  
Affinity Capture-MS Homo sapiens
42 C21orf33  
Proximity Label-MS Homo sapiens
43 RIPK4  
Affinity Capture-MS Homo sapiens
44 COX8A  
Proximity Label-MS Homo sapiens
45 APP 351
Reconstituted Complex Homo sapiens
46 HSF2  
Affinity Capture-MS Homo sapiens
47 TUFM 7284
Proximity Label-MS Homo sapiens
48 ECI2 10455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ACOT13  
Co-fractionation Homo sapiens
50 KIAA1429 25962
Affinity Capture-MS Homo sapiens
51 MAPK6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 C1QBP 708
Proximity Label-MS Homo sapiens
53 EEF2KMT  
Affinity Capture-MS Homo sapiens
54 NDUFS3 4722
Affinity Capture-MS Homo sapiens
55 MYC  
Affinity Capture-MS Homo sapiens
56 TFAM 7019
Proximity Label-MS Homo sapiens
57 Tpx2  
Affinity Capture-MS Mus musculus
58 KIF23 9493
Affinity Capture-MS Homo sapiens
59 COQ9  
Affinity Capture-MS Homo sapiens
60 NDUFA7 4701
Co-fractionation Homo sapiens
61 HERC2 8924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 TNNC2  
Affinity Capture-MS Homo sapiens
63 NDUFA2 4695
Co-fractionation Homo sapiens
64 ACAD9 28976
Proximity Label-MS Homo sapiens
65 SERBP1 26135
Affinity Capture-MS Homo sapiens
66 PEX5 5830
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
67 MRPL12 6182
Affinity Capture-MS Homo sapiens
68 CYB5R3 1727
Cross-Linking-MS (XL-MS) Homo sapiens
69 METTL17  
Proximity Label-MS Homo sapiens
70 PDZK1 5174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 AGPS 8540
Proximity Label-MS Homo sapiens
72 PDGFD 80310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
74 MAP7D2 256714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 USP20  
Affinity Capture-MS Homo sapiens
76 TRAF1 7185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 RPA3 6119
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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