Gene description for QDPR
Gene name quinoid dihydropteridine reductase
Gene symbol QDPR
Other names/aliases DHPR
PKU2
SDR33C1
Species Homo sapiens
 Database cross references - QDPR
ExoCarta ExoCarta_5860
Entrez Gene 5860
HGNC 9752
MIM 612676
UniProt P09417  
 QDPR identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for QDPR
Molecular Function
    NADPH binding GO:0070402 IEA
    electron carrier activity GO:0009055 TAS
    6,7-dihydropteridine reductase activity GO:0004155 EXP
    NADH binding GO:0070404 IEA
    protein homodimerization activity GO:0042803 IEA
Biological Process
    liver development GO:0001889 IEA
    tetrahydrobiopterin biosynthetic process GO:0006729 IEA
    small molecule metabolic process GO:0044281 TAS
    response to aluminum ion GO:0010044 IEA
    cellular response to drug GO:0035690 IEA
    dihydrobiopterin metabolic process GO:0051066 TAS
    cellular amino acid metabolic process GO:0006520 TAS
    L-phenylalanine catabolic process GO:0006559 TAS
    oxidation-reduction process GO:0055114 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    response to glucagon GO:0033762 IEA
    response to lead ion GO:0010288 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
    mitochondrion GO:0005739 IEA
    neuron projection GO:0043005 IEA
 Experiment description of studies that identified QDPR in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for QDPR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PAH 5053
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which QDPR is involved
PathwayEvidenceSource
Phenylalanine and tyrosine catabolism TAS Reactome





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