Gene description for BTG1
Gene name B-cell translocation gene 1, anti-proliferative
Gene symbol BTG1
Other names/aliases -
Species Homo sapiens
 Database cross references - BTG1
ExoCarta ExoCarta_694
Entrez Gene 694
HGNC 1130
MIM 109580
UniProt P62324  
 BTG1 identified in exosomes derived from the following tissue/cell type
Malignant pleural effusions 14975938    
Malignant pleural effusions 14975938    
 Gene ontology annotations for BTG1
Molecular Function
    protein binding GO:0005515 IPI
    transcription cofactor activity GO:0003712 NAS
    kinase binding GO:0019900 NAS
    enzyme binding GO:0019899 IPI
Biological Process
    positive regulation of angiogenesis GO:0045766 IMP
    negative regulation of cell growth GO:0030308 NAS
    cell migration GO:0016477 NAS
    regulation of transcription, DNA-templated GO:0006355 NAS
    positive regulation of fibroblast apoptotic process GO:2000271 IMP
    positive regulation of myoblast differentiation GO:0045663 NAS
    positive regulation of endothelial cell differentiation GO:0045603 IMP
    negative regulation of cell proliferation GO:0008285 IDA
Subcellular Localization
    nucleus GO:0005634 IMP
    cytoplasm GO:0005737 IMP
 Experiment description of studies that identified BTG1 in exosomes
1
Experiment ID 51
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP90
EV Cytosolic markers
✔
MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Breast cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
2
Experiment ID 52
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP90
EV Cytosolic markers
✔
MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Lung cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for BTG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HOXB9  
Two-hybrid Homo sapiens
Far Western Homo sapiens
2 PRMT1 3276
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 CNOT8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 CNOT7 29883
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BTG1 is involved
No pathways found





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