Gene description for Cops6
Gene name COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)
Gene symbol Cops6
Other names/aliases Sgn3
VIP/MOV34
Species Mus musculus
 Database cross references - Cops6
ExoCarta ExoCarta_26893
Vesiclepedia VP_26893
Entrez Gene 26893
UniProt O88545  
 Cops6 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Cops6
Molecular Function
    protein binding GO:0005515 IPI
    metallopeptidase activity GO:0008237 IEA
Biological Process
    protein deneddylation GO:0000338 IEA
    protein deneddylation GO:0000338 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IDA
    COP9 signalosome GO:0008180 ISO
 Experiment description of studies that identified Cops6 in exosomes
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cops6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Id3  
Far Western Mus musculus
2 Cops5 26754
Affinity Capture-Western Mus musculus
3 Ubc  
Reconstituted Complex Mus musculus
4 COPS5 10987
Affinity Capture-Western Homo sapiens
5 COPS3 8533
Affinity Capture-Western Homo sapiens
6 Synm  
Co-fractionation Mus musculus
7 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 COPS8 10920
Affinity Capture-Western Homo sapiens
9 Krt2 16681
Co-fractionation Mus musculus
10 GPS1 2873
Affinity Capture-Western Homo sapiens
11 CUL2 8453
Affinity Capture-Western Homo sapiens
12 Socs3  
Affinity Capture-Western Mus musculus
13 COPS2 9318
Affinity Capture-Western Homo sapiens
14 Cops2 12848
Affinity Capture-Western Mus musculus
15 Chaf1a  
Affinity Capture-MS Mus musculus
16 Cops4 26891
Two-hybrid Mus musculus
17 Gps1 209318
Affinity Capture-Western Mus musculus
18 Snrpd1 20641
Co-fractionation Mus musculus
View the network image/svg+xml



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