Gene description for Krt2
Gene name keratin 2
Gene symbol Krt2
Other names/aliases BB005427
Krt2-17
Krt2-2
Krt2e
Species Mus musculus
 Database cross references - Krt2
ExoCarta ExoCarta_16681
Vesiclepedia VP_16681
Entrez Gene 16681
UniProt Q3TTY5  
 Krt2 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt2
Molecular Function
    cytoskeletal protein binding GO:0008092 IMP
    structural constituent of skin epidermis GO:0030280 IBA
    structural constituent of skin epidermis GO:0030280 IMP
    structural constituent of skin epidermis GO:0030280 ISO
Biological Process
    keratinocyte development GO:0003334 IMP
    epidermis development GO:0008544 IMP
    peptide cross-linking GO:0018149 ISO
    keratinization GO:0031424 IBA
    keratinization GO:0031424 IEA
    keratinization GO:0031424 ISO
    keratinocyte activation GO:0032980 IEA
    keratinocyte activation GO:0032980 ISO
    keratinocyte proliferation GO:0043616 IEA
    keratinocyte proliferation GO:0043616 ISO
    intermediate filament organization GO:0045109 IBA
    intermediate filament organization GO:0045109 IMP
    positive regulation of epidermis development GO:0045684 IMP
    keratinocyte migration GO:0051546 IEA
    keratinocyte migration GO:0051546 ISO
Subcellular Localization
    cornified envelope GO:0001533 IEA
    cornified envelope GO:0001533 ISO
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IDA
 Experiment description of studies that identified Krt2 in exosomes
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nphp3  
Affinity Capture-MS Mus musculus
2 Invs  
Affinity Capture-MS Mus musculus
3 Cops6 26893
Co-fractionation Mus musculus
4 Nphp4  
Affinity Capture-MS Mus musculus
5 Evpl  
Co-fractionation Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Thrb  
Affinity Capture-MS Mus musculus
8 Cul4b  
Co-fractionation Mus musculus
9 Ahi1  
Affinity Capture-MS Mus musculus
10 Cul4a  
Co-fractionation Mus musculus
11 Nphp1  
Affinity Capture-MS Mus musculus
12 Mks1  
Affinity Capture-MS Mus musculus
13 Iqcb1  
Affinity Capture-MS Mus musculus
14 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Krt2 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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