Gene description for Gps1
Gene name G protein pathway suppressor 1
Gene symbol Gps1
Other names/aliases Cops1
Csn1
R75577
Sgn1
Species Mus musculus
 Database cross references - Gps1
ExoCarta ExoCarta_209318
Vesiclepedia VP_209318
Entrez Gene 209318
 Gps1 identified in exosomes derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Gps1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein deneddylation GO:0000338 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IDA
    COP9 signalosome GO:0008180 ISO
 Experiment description of studies that identified Gps1 in exosomes
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Gps1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Skp1a 21402
Co-fractionation Mus musculus
2 Cops5 26754
Affinity Capture-Western Mus musculus
3 Ubc  
Reconstituted Complex Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 CUL1 8454
Affinity Capture-MS Homo sapiens
6 Cops4 26891
Affinity Capture-Western Mus musculus
7 Cops7b  
Affinity Capture-Western Mus musculus
8 Cops3  
Affinity Capture-Western Mus musculus
9 Cops2 12848
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
10 Cops8 108679
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
11 Cops7a 26894
Affinity Capture-Western Mus musculus
12 Gsk3b  
Biochemical Activity Mus musculus
13 Chaf1a  
Affinity Capture-MS Mus musculus
14 Sap130  
Affinity Capture-Western Mus musculus
15 ASB4  
Affinity Capture-Western Homo sapiens
16 Cops6 26893
Affinity Capture-Western Mus musculus
17 Epb4.1l2 13822
Co-fractionation Mus musculus
18 Tmod1  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Gps1 is involved
No pathways found





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