Gene description for Epb4.1l2
Gene name erythrocyte protein band 4.1-like 2
Gene symbol Epb4.1l2
Other names/aliases 4.1G
AW555191
D10Ertd398e
Epb41l2
NBL2
Species Mus musculus
 Database cross references - Epb4.1l2
ExoCarta ExoCarta_13822
Entrez Gene 13822
UniProt O70318  
 Epb4.1l2 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Epb4.1l2
Molecular Function
    cytoskeletal protein binding GO:0008092 IEA
    protein binding GO:0005515 IPI
    actin binding GO:0003779 ISS
    PH domain binding GO:0042731 IDA
    structural molecule activity GO:0005198 IEA
    spectrin binding GO:0030507 ISS
Biological Process
    actin cytoskeleton organization GO:0030036 ISS
    regulation of cell shape GO:0008360 ISS
    cortical actin cytoskeleton organization GO:0030866 IEA
Subcellular Localization
    plasma membrane GO:0005886 ISO
    nucleus GO:0005634 ISO
    actin cytoskeleton GO:0015629 ISS
    cytoplasm GO:0005737 IEA
    extrinsic component of membrane GO:0019898 IEA
    COP9 signalosome GO:0008180 ISO
    cell junction GO:0030054 ISO
    cytoskeleton GO:0005856 IEA
    focal adhesion GO:0005925 ISO
    extracellular exosome GO:0070062 ISO
    nucleoplasm GO:0005654 ISO
    membrane GO:0016020 IEA
 Experiment description of studies that identified Epb4.1l2 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Epb4.1l2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Epb4.1l2 is involved
No pathways found





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