Gene description for Cops7a
Gene name COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
Gene symbol Cops7a
Other names/aliases D6Ertd35e
Species Mus musculus
 Database cross references - Cops7a
ExoCarta ExoCarta_26894
Vesiclepedia VP_26894
Entrez Gene 26894
UniProt Q9CZ04  
 Cops7a identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Cops7a
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    protein deneddylation GO:0000338 IEA
    protein deneddylation GO:0000338 ISO
    COP9 signalosome assembly GO:0010387 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IEA
    COP9 signalosome GO:0008180 ISO
 Experiment description of studies that identified Cops7a in exosomes
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cops7a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Id3  
Reconstituted Complex Mus musculus
2 Ubc  
Reconstituted Complex Mus musculus
3 CUL1 8454
Affinity Capture-MS Homo sapiens
4 Socs3  
Affinity Capture-Western Mus musculus
5 Cops2 12848
Affinity Capture-Western Mus musculus
6 Cul4b  
Co-fractionation Mus musculus
7 Gps1 209318
Affinity Capture-Western Mus musculus
8 Epb4.1l2 13822
Co-fractionation Mus musculus
View the network image/svg+xml



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