Gene description for FBXO18
Gene name F-box protein, helicase, 18
Gene symbol FBXO18
Other names/aliases FBH1
Fbx18
Species Homo sapiens
 Database cross references - FBXO18
ExoCarta ExoCarta_84893
Entrez Gene 84893
HGNC 13620
MIM 607222
UniProt Q8NFZ0  
 FBXO18 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for FBXO18
Molecular Function
    DNA binding GO:0003677 IEA
    DNA translocase activity GO:0015616 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP-dependent DNA helicase activity GO:0004003 IEA
Biological Process
    positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902231 IMP
    DNA catabolic process, endonucleolytic GO:0000737 IMP
    response to intra-S DNA damage checkpoint signaling GO:0072429 IMP
    positive regulation of protein phosphorylation GO:0001934 IMP
    DNA duplex unwinding GO:0032508 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified FBXO18 in exosomes
1
Experiment ID 234
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for FBXO18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBX1 9978
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 SKP1 6500
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
3 CUL1 8454
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which FBXO18 is involved
No pathways found





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