Gene description for MTSS1
Gene name metastasis suppressor 1
Gene symbol MTSS1
Other names/aliases MIM
MIMA
MIMB
Species Homo sapiens
 Database cross references - MTSS1
ExoCarta ExoCarta_9788
Vesiclepedia VP_9788
Entrez Gene 9788
HGNC 20443
MIM 608486
UniProt O43312  
 MTSS1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for MTSS1
Molecular Function
    actin binding GO:0003779 IBA
    actin monomer binding GO:0003785 IDA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IBA
    identical protein binding GO:0042802 IPI
Biological Process
    plasma membrane organization GO:0007009 IEA
    cell adhesion GO:0007155 NAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    microspike assembly GO:0030035 NAS
    actin cytoskeleton organization GO:0030036 TAS
    positive regulation of actin filament bundle assembly GO:0032233 IBA
    adherens junction maintenance GO:0034334 IBA
    negative regulation of epithelial cell proliferation GO:0050680 ISS
    renal tubule morphogenesis GO:0061333 ISS
    cellular response to fluid shear stress GO:0071498 ISS
    glomerulus morphogenesis GO:0072102 ISS
    nephron tubule epithelial cell differentiation GO:0072160 ISS
    epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013 ISS
Subcellular Localization
    ruffle GO:0001726 NAS
    cytoplasm GO:0005737 TAS
    cytoplasmic side of plasma membrane GO:0009898 IBA
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IDA
    endocytic vesicle GO:0030139 TAS
 Experiment description of studies that identified MTSS1 in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MTSS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTSS1L 92154
Affinity Capture-MS Homo sapiens
2 RELA 5970
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 RECQL5  
Two-hybrid Homo sapiens
4 EIF3F 8665
Affinity Capture-MS Homo sapiens
5 CUL1 8454
Affinity Capture-Western Homo sapiens
6 BTRC 8945
Affinity Capture-Western Homo sapiens
7 FBXW11  
Affinity Capture-MS Homo sapiens
8 CSNK1D 1453
Affinity Capture-Western Homo sapiens
9 CXCR4 7852
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 PSMC3 5702
Affinity Capture-MS Homo sapiens
11 RAB5A 5868
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 PSMD11 5717
Affinity Capture-MS Homo sapiens
13 CD274 29126
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 SKP1 6500
Affinity Capture-Western Homo sapiens
15 ACTBL2 345651
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
16 RBX1 9978
Affinity Capture-Western Homo sapiens
17 MTSS1 9788
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 TRIM28 10155
Affinity Capture-MS Homo sapiens
19 EEF1E1 9521
Affinity Capture-MS Homo sapiens
20 SLC3A2 6520
Affinity Capture-MS Homo sapiens
21 TRIM21 6737
Affinity Capture-MS Homo sapiens
22 RAB7A 7879
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 HGS 9146
Affinity Capture-Western Homo sapiens
24 MZF1  
Affinity Capture-RNA Homo sapiens
Protein-RNA Homo sapiens
25 ITCH 83737
Affinity Capture-Western Homo sapiens
26 RBCK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MTSS1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here