Gene description for MTSS1
Gene name metastasis suppressor 1
Gene symbol MTSS1
Other names/aliases MIM
MIMA
MIMB
Species Homo sapiens
 Database cross references - MTSS1
ExoCarta ExoCarta_9788
Entrez Gene 9788
HGNC 20443
MIM 608486
UniProt O43312  
 MTSS1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for MTSS1
Molecular Function
    actin monomer binding GO:0003785 IDA
    receptor binding GO:0005102 IPI
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 IEA
Biological Process
    negative regulation of epithelial cell proliferation GO:0050680 ISS
    glomerulus morphogenesis GO:0072102 ISS
    cell adhesion GO:0007155 NAS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    actin filament polymerization GO:0030041 IEA
    in utero embryonic development GO:0001701 IEA
    positive regulation of actin filament bundle assembly GO:0032233 IEA
    nephron tubule epithelial cell differentiation GO:0072160 ISS
    renal tubule morphogenesis GO:0061333 ISS
    positive regulation of defense response to virus by host GO:0002230 IMP
    cellular response to fluid shear stress GO:0071498 ISS
    epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013 ISS
    adherens junction maintenance GO:0034334 IEA
    magnesium ion homeostasis GO:0010960 IEA
    bone mineralization GO:0030282 IEA
    actin cytoskeleton organization GO:0030036 TAS
    movement of cell or subcellular component GO:0006928 NAS
    microspike assembly GO:0030035 NAS
    plasma membrane organization GO:0007009 IEA
Subcellular Localization
    ruffle GO:0001726 NAS
    adherens junction GO:0005912 IEA
    actin cytoskeleton GO:0015629 IDA
    cytoplasm GO:0005737 TAS
    endocytic vesicle GO:0030139 TAS
 Experiment description of studies that identified MTSS1 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MTSS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RECQL5  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MTSS1 is involved
No pathways found





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