Gene description for ZNF674
Gene name zinc finger protein 674
Gene symbol ZNF674
Other names/aliases MRX92
ZNF673B
Species Homo sapiens
 Database cross references - ZNF674
ExoCarta ExoCarta_641339
Vesiclepedia VP_641339
Entrez Gene 641339
HGNC 17625
MIM 300573
UniProt Q2M3X9  
 ZNF674 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZNF674
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified ZNF674 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZNF674
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERPINB4 6318
Affinity Capture-MS Homo sapiens
2 CUL3 8452
Affinity Capture-MS Homo sapiens
3 S100A7 6278
Affinity Capture-MS Homo sapiens
4 SERPINA3 12
Affinity Capture-MS Homo sapiens
5 S100A7A 338324
Affinity Capture-MS Homo sapiens
6 TRIM28 10155
Affinity Capture-MS Homo sapiens
7 SBSN 374897
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF674 is involved
No pathways found





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