Gene description for SPOCK1
Gene name sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
Gene symbol SPOCK1
Other names/aliases SPOCK
TESTICAN
TIC1
Species Homo sapiens
 Database cross references - SPOCK1
ExoCarta ExoCarta_6695
Entrez Gene 6695
HGNC 11251
MIM 602264
UniProt Q08629  
 SPOCK1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SPOCK1
Molecular Function
    calcium ion binding GO:0005509 IDA
    serine-type endopeptidase inhibitor activity GO:0004867 NAS
    metalloendopeptidase inhibitor activity GO:0008191 IDA
    cysteine-type endopeptidase inhibitor activity GO:0004869 IDA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IDA
    nervous system development GO:0007399 NAS
    regulation of cell growth GO:0001558 NAS
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    neurogenesis GO:0022008 ISS
    signal transduction GO:0007165 IEA
    neuron migration GO:0001764 ISS
    cell adhesion GO:0007155 NAS
    central nervous system neuron differentiation GO:0021953 ISS
    negative regulation of neuron projection development GO:0010977 IDA
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IEA
    node of Ranvier GO:0033268 ISS
    extracellular space GO:0005615 IDA
    neuromuscular junction GO:0031594 ISS
    postsynaptic density GO:0014069 NAS
    sarcoplasm GO:0016528 ISS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified SPOCK1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SPOCK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SPOCK1 is involved
No pathways found





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