Gene description for HMGB3
Gene name high mobility group box 3
Gene symbol HMGB3
Other names/aliases HMG-2a
HMG-4
HMG2A
HMG4
Species Homo sapiens
 Database cross references - HMGB3
ExoCarta ExoCarta_3149
Entrez Gene 3149
HGNC 5004
MIM 300193
UniProt O15347  
 HMGB3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for HMGB3
Molecular Function
    DNA binding, bending GO:0008301 ISS
    double-stranded DNA binding GO:0003690 ISS
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    chromatin binding GO:0003682 IBA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IBA
    negative regulation of B cell differentiation GO:0045578 IEA
    multicellular organismal development GO:0007275 TAS
    chromatin remodeling GO:0006338 IBA
    DNA recombination GO:0006310 ISS
    negative regulation of myeloid cell differentiation GO:0045638 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    chromosome GO:0005694 IEA
 Experiment description of studies that identified HMGB3 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for HMGB3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HMGB3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here