Gene description for ZCCHC4
Gene name zinc finger, CCHC domain containing 4
Gene symbol ZCCHC4
Other names/aliases HSPC052
ZGRF4
Species Homo sapiens
 Database cross references - ZCCHC4
ExoCarta ExoCarta_29063
Entrez Gene 29063
HGNC 22917
MIM 611792
UniProt Q9H5U6  
 ZCCHC4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ZCCHC4
Molecular Function
    methyltransferase activity GO:0008168 IEA
    nucleic acid binding GO:0003676 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    methylation GO:0032259 IEA
 Experiment description of studies that identified ZCCHC4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ZCCHC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ZCCHC4 is involved
No pathways found





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