Gene description for URB1
Gene name URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Gene symbol URB1
Other names/aliases C21orf108
NPA1
Species Homo sapiens
 Database cross references - URB1
ExoCarta ExoCarta_9875
Vesiclepedia VP_9875
Entrez Gene 9875
HGNC 17344
MIM 608865
UniProt O60287  
 URB1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for URB1
Molecular Function
    RNA binding GO:0003723 HDA
Biological Process
    maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000463 IBA
    maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000466 IBA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 NAS
 Experiment description of studies that identified URB1 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for URB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF668  
Affinity Capture-MS Homo sapiens
2 RPL26L1 51121
Affinity Capture-MS Homo sapiens
3 LGR4 55366
Affinity Capture-MS Homo sapiens
4 COIL  
Proximity Label-MS Homo sapiens
5 ANLN 54443
Affinity Capture-MS Homo sapiens
6 Sesn2  
Affinity Capture-MS Mus musculus
7 RPL13A 23521
Affinity Capture-MS Homo sapiens
8 NOP56 10528
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
9 KIF20A 10112
Affinity Capture-MS Homo sapiens
10 TAB1 10454
Two-hybrid Homo sapiens
11 RPL14 9045
Affinity Capture-MS Homo sapiens
12 FGF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 FPR1  
Affinity Capture-MS Homo sapiens
14 ZNF653  
Affinity Capture-MS Homo sapiens
15 CENPA  
Proximity Label-MS Homo sapiens
16 DNAJB6 10049
Proximity Label-MS Homo sapiens
17 APEX1 328
Proximity Label-MS Homo sapiens
18 NOL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DDX23 9416
Proximity Label-MS Homo sapiens
20 PLEKHO1 51177
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RPL10A 4736
Affinity Capture-MS Homo sapiens
22 LLPH  
Affinity Capture-MS Homo sapiens
23 H1FX 8971
Cross-Linking-MS (XL-MS) Homo sapiens
24 PRC1 9055
Affinity Capture-MS Homo sapiens
25 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ANOS1 3730
Affinity Capture-MS Homo sapiens
27 FBL 2091
Proximity Label-MS Homo sapiens
28 POLR1E  
Proximity Label-MS Homo sapiens
29 OBSL1 23363
Affinity Capture-MS Homo sapiens
30 SURF6  
Affinity Capture-MS Homo sapiens
31 ADARB1 104
Affinity Capture-MS Homo sapiens
32 PRKRA 8575
Affinity Capture-MS Homo sapiens
33 TACSTD2 4070
Affinity Capture-MS Homo sapiens
34 Nhp2l1 20826
Affinity Capture-MS Mus musculus
35 RRP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 H2AFY2 55506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 GPR17 2840
Affinity Capture-MS Homo sapiens
39 KIF14 9928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 BAG6 7917
Affinity Capture-MS Homo sapiens
41 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
42 DDX21 9188
Affinity Capture-MS Homo sapiens
43 CDC23 8697
Affinity Capture-MS Homo sapiens
44 Ncapg2  
Affinity Capture-MS Mus musculus
45 RPL4 6124
Affinity Capture-MS Homo sapiens
46 Ppp4c 56420
Affinity Capture-MS Mus musculus
47 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
48 SRSF6 6431
Affinity Capture-MS Homo sapiens
49 NOP2 4839
Affinity Capture-MS Homo sapiens
50 RPL18A 6142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 Srp72  
Affinity Capture-MS Mus musculus
52 CHMP4B 128866
Affinity Capture-MS Homo sapiens
53 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 GPR182  
Affinity Capture-MS Homo sapiens
55 RPL36 25873
Affinity Capture-MS Homo sapiens
56 HUWE1 10075
Affinity Capture-MS Homo sapiens
57 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
58 HECTD1 25831
Affinity Capture-MS Homo sapiens
59 RPLP0 6175
Affinity Capture-MS Homo sapiens
60 MAGEB2 4113
Affinity Capture-MS Homo sapiens
61 FGF13  
Affinity Capture-MS Homo sapiens
62 CD3EAP  
Proximity Label-MS Homo sapiens
63 CCDC59  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 FGFBP1 9982
Affinity Capture-MS Homo sapiens
65 EFNA4  
Affinity Capture-MS Homo sapiens
66 RPL31 6160
Proximity Label-MS Homo sapiens
67 ABT1 29777
Affinity Capture-MS Homo sapiens
68 RPL15 6138
Affinity Capture-MS Homo sapiens
69 EIF6 3692
Proximity Label-MS Homo sapiens
70 SIRT7  
Affinity Capture-MS Homo sapiens
71 NPM3 10360
Affinity Capture-MS Homo sapiens
72 RPL3 6122
Affinity Capture-MS Homo sapiens
73 EGFR 1956
Negative Genetic Homo sapiens
74 TFG 10342
Affinity Capture-MS Homo sapiens
75 OCIAD1 54940
Affinity Capture-MS Homo sapiens
76 NXF1 10482
Affinity Capture-RNA Homo sapiens
77 ZNF512  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 MAPK6  
Two-hybrid Homo sapiens
79 DGKZ  
Affinity Capture-MS Homo sapiens
80 RPA3 6119
Proximity Label-MS Homo sapiens
81 NLRP3  
Affinity Capture-MS Homo sapiens
82 RPS14 6208
Affinity Capture-MS Homo sapiens
83 RPL22 6146
Affinity Capture-MS Homo sapiens
84 RPL18 6141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 H2AFB2  
Affinity Capture-MS Homo sapiens
86 DDX55  
Affinity Capture-MS Homo sapiens
87 Ccdc9  
Affinity Capture-MS Mus musculus
88 RPL13 6137
Affinity Capture-MS Homo sapiens
89 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
90 Tubg1 103733
Affinity Capture-MS Mus musculus
91 PARP1 142
Proximity Label-MS Homo sapiens
92 ILF3 3609
Affinity Capture-MS Homo sapiens
93 MNDA 4332
Affinity Capture-MS Homo sapiens
94 USP36  
Affinity Capture-MS Homo sapiens
95 ZNF48  
Affinity Capture-MS Homo sapiens
96 NIFK 84365
Proximity Label-MS Homo sapiens
97 Mta1  
Affinity Capture-MS Mus musculus
98 DHX40  
Proximity Label-MS Homo sapiens
99 RBM4 5936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 NEIL1  
Affinity Capture-MS Homo sapiens
101 RPS24 6229
Proximity Label-MS Homo sapiens
102 Dctn3  
Affinity Capture-MS Mus musculus
103 C16orf72 29035
Affinity Capture-MS Homo sapiens
104 SORT1 6272
Affinity Capture-MS Homo sapiens
105 RPL23AP32 56969
Affinity Capture-MS Homo sapiens
106 RPS6 6194
Proximity Label-MS Homo sapiens
107 RPL28 6158
Affinity Capture-MS Homo sapiens
108 KRAS 3845
Negative Genetic Homo sapiens
109 Ufl1  
Affinity Capture-MS Mus musculus
110 C9orf72  
Affinity Capture-MS Homo sapiens
111 RBM34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 ZNF467  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which URB1 is involved
No pathways found





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