Gene description for SOX1
Gene name SRY (sex determining region Y)-box 1
Gene symbol SOX1
Other names/aliases -
Species Homo sapiens
 Database cross references - SOX1
ExoCarta ExoCarta_6656
Vesiclepedia VP_6656
Entrez Gene 6656
HGNC 11189
MIM 602148
UniProt O00570  
 SOX1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SOX1
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
    DNA binding GO:0003677 NAS
    core promoter sequence-specific DNA binding GO:0001046 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of transcription, DNA-templated GO:0006355 NAS
    forebrain neuron development GO:0021884 IEA
    transcription, DNA-templated GO:0006351 IEA
    neuron migration GO:0001764 IEA
    chromatin organization GO:0006325 NAS
    ventral spinal cord interneuron specification GO:0021521 IEA
    lens morphogenesis in camera-type eye GO:0002089 IEA
Subcellular Localization
    nucleus GO:0005634 NAS
 Experiment description of studies that identified SOX1 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101|CD63|CD81
EV Enriched markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SOX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SOX1 is involved
No pathways found





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