Gene description for SFMBT1
Gene name Scm-like with four mbt domains 1
Gene symbol SFMBT1
Other names/aliases RU1
Species Homo sapiens
 Database cross references - SFMBT1
ExoCarta ExoCarta_51460
Entrez Gene 51460
HGNC 20255
MIM 607319
UniProt Q9UHJ3  
 SFMBT1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SFMBT1
Molecular Function
    histone binding GO:0042393 IDA
    transcription corepressor activity GO:0003714 TAS
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of muscle organ development GO:0048635 IMP
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    transcription, DNA-templated GO:0006351 IEA
    chromatin modification GO:0016568 IEA
    spermatogenesis GO:0007283 IEA
    cell differentiation GO:0030154 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified SFMBT1 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SFMBT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PHC1  
Two-hybrid Homo sapiens
2 ACP1 52
Two-hybrid Homo sapiens
3 PHC2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SFMBT1 is involved
No pathways found

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