Gene description for CLDN12
Gene name claudin 12
Gene symbol CLDN12
Other names/aliases -
Species Homo sapiens
 Database cross references - CLDN12
ExoCarta ExoCarta_9069
Vesiclepedia VP_9069
Entrez Gene 9069
HGNC 2034
MIM 611232
UniProt P56749  
 CLDN12 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for CLDN12
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISS
Biological Process
    calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 ISS
    maintenance of blood-brain barrier GO:0035633 NAS
    tight junction assembly GO:0120192 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    bicellular tight junction GO:0005923 ISS
    lateral plasma membrane GO:0016328 IEA
 Experiment description of studies that identified CLDN12 in exosomes
1
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for CLDN12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRN4 29888
Two-hybrid Homo sapiens
2 TUSC5  
Two-hybrid Homo sapiens
3 C12orf49  
Negative Genetic Homo sapiens
4 FUCA2 2519
Affinity Capture-MS Homo sapiens
5 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
6 SEC13 6396
Two-hybrid Homo sapiens
7 ECHS1 1892
Two-hybrid Homo sapiens
View the network image/svg+xml



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