Gene description for SESN2
Gene name sestrin 2
Gene symbol SESN2
Other names/aliases HI95
SES2
SEST2
Species Homo sapiens
 Database cross references - SESN2
ExoCarta ExoCarta_83667
Vesiclepedia VP_83667
Entrez Gene 83667
HGNC 20746
MIM 607767
UniProt P58004  
 SESN2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SESN2
Molecular Function
    peroxidase activity GO:0004601 IDA
    GDP-dissociation inhibitor activity GO:0005092 IEA
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on peroxide as acceptor GO:0016684 IBA
    sulfiredoxin activity GO:0032542 IDA
    sulfiredoxin activity GO:0032542 IDA
    PH domain binding GO:0042731 IEA
    protein-containing complex binding GO:0044877 IPI
    protein-containing complex binding GO:0044877 IPI
    L-leucine binding GO:0070728 IBA
    L-leucine binding GO:0070728 IDA
    protein sequestering activity GO:0140311 IDA
Biological Process
    regulation of protein phosphorylation GO:0001932 IDA
    regulation of gluconeogenesis GO:0006111 IEA
    fatty acid beta-oxidation GO:0006635 IEA
    response to glucose GO:0009749 IEA
    positive regulation of macroautophagy GO:0016239 IBA
    positive regulation of macroautophagy GO:0016239 IMP
    negative regulation of cell growth GO:0030308 ISS
    DNA damage response, signal transduction by p53 class mediator GO:0030330 IMP
    mitochondrial DNA metabolic process GO:0032042 IEA
    response to insulin GO:0032868 IEA
    cellular response to amino acid starvation GO:0034198 IMP
    cellular response to oxidative stress GO:0034599 ISS
    cellular response to glucose starvation GO:0042149 IMP
    glucose homeostasis GO:0042593 IEA
    D-glucose import GO:0046323 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    triglyceride homeostasis GO:0070328 IEA
    cellular response to amino acid stimulus GO:0071230 IMP
    cellular response to L-leucine GO:0071233 IBA
    cellular response to L-leucine GO:0071233 IDA
    cellular response to L-leucine GO:0071233 IMP
    reactive oxygen species metabolic process GO:0072593 IDA
    reactive oxygen species metabolic process GO:0072593 IMP
    cellular oxidant detoxification GO:0098869 IDA
    cellular oxidant detoxification GO:0098869 IDA
    cellular oxidant detoxification GO:0098869 IMP
    positive regulation of protein localization to nucleus GO:1900182 IMP
    regulation of response to reactive oxygen species GO:1901031 IEA
    negative regulation of translation in response to endoplasmic reticulum stress GO:1902010 IMP
    regulation of TORC1 signaling GO:1903432 IDA
    negative regulation of TORC1 signaling GO:1904262 IBA
    negative regulation of TORC1 signaling GO:1904262 IDA
    negative regulation of TORC1 signaling GO:1904262 IMP
    positive regulation of TORC1 signaling GO:1904263 IDA
    positive regulation of lipophagy GO:1904504 IEA
    cellular response to leucine starvation GO:1990253 IBA
    cellular response to leucine starvation GO:1990253 IDA
    cellular response to leucine starvation GO:1990253 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IEA
    lysosomal membrane GO:0005765 IDA
    cytosol GO:0005829 TAS
    nucleotide-activated protein kinase complex GO:0031588 ISS
    TORC2 complex GO:0031932 ISS
    Atg1/ULK1 kinase complex GO:1990316 IPI
 Experiment description of studies that identified SESN2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SESN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GYPA  
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 FASN 2194
Negative Genetic Homo sapiens
4 WDR5 11091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 NPRL2  
Affinity Capture-Western Homo sapiens
6 RNF167 26001
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
7 ATG9A 79065
Proximity Label-MS Homo sapiens
8 NPRL3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 SEC13 6396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 KEAP1 9817
Affinity Capture-Western Homo sapiens
11 EDEM1  
Affinity Capture-MS Homo sapiens
12 DEPDC5  
Affinity Capture-MS Homo sapiens
13 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
14 RBX1 9978
Affinity Capture-Western Homo sapiens
15 EGFR 1956
Affinity Capture-MS Homo sapiens
16 DHX57 90957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DDX58 23586
Affinity Capture-RNA Homo sapiens
18 SZT2 23334
Affinity Capture-Western Homo sapiens
19 RB1CC1 9821
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 ATG13 9776
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 MIOS 54468
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 WDR24  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 PRDX1 5052
Affinity Capture-Western Homo sapiens
24 WDR59 79726
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
25 METAP2 10988
Affinity Capture-Western Homo sapiens
26 ULK1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 STAMBPL1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
28 RBBP5 5929
Affinity Capture-MS Homo sapiens
29 MDM2  
Two-hybrid Homo sapiens
30 EP300 2033
Affinity Capture-MS Homo sapiens
31 VCP 7415
Affinity Capture-MS Homo sapiens
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